How many domains are in EGFR?
four domains
(A) The domain composition of human EGFR is shown. The extracellular region contains four domains: Domain I (amino acids 1–165), domain II (amino acids 165–310), domain III (amino acids 310–480), and domain IV (amino acids 480–620). Domains I and III are closely related in sequence, as are domains II and IV.
What receptor does EGF bind to?
4.2. EGFR is a member of the ErbB receptor family and binds to several ligands of which epidermal growth factor (EGF) is best known. EGFR signaling is crucial for the development of several organs including skin (reviewed in Ref. 116).
What is activated by EGF?
The aberrant activation of EGFR is implicated in a variety of human cancers [5]. The receptor is activated by the binding of various ligands including epidermal growth factor (EGF), transforming growth factor α (TGFα), amphiregulin (AREG), epigen, β-cellulin, heparin-binding EGF (HB-EGF), and epiregulin [6,7].
What type of signaling is EGF?
The binding between EGFR and ligand triggers series of downstream intracellular signaling transduction.
What is the structure of EGFR?
The epidermal growth factor receptor (EGFR) is a single-chain transmembrane protein comprised of an extracellular EGF-binding domain, a short transmembrane sequence, and a cytoplasmic region that incorporates a protein tyrosine kinase domain and a C-terminal phosphorylation domain.
How does EGF bind to EGFR?
Binding of EGF to the EGFR leads to the transphosphorylation of various tyrosine residues on the intracellular C-terminal tail. The tyrosine residues phosphorylated by EGF addition to cells include Y703, Y920, Y992, Y1045, Y1068, Y1086, Y1148, and Y1173.
How does EGF create biological response?
EGF Receptors have an ability to escape lysosomal degradation and translocate into the nucleus to mediate biological functions. In the nucleus, these receptors promote transcription of cell survival genes like Cyclin D1 gene and also act as cofactors for STAT and E2F1 transcription factors18.
What does the EGF pathway do?
The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells.
What is the role of EGF in a cell signaling pathway?
EGFR plays a crucial role in initiating the signaling that directs the behavior of epithelial cells and tumors of epithelial origin. Human EGF is a 53-aa polypeptide, whose molecular weight is 6KDa. EGF can stimulate the cell growth and differentiation by binding to its receptor, EGFR.
Where are EGFR?
Epidermal growth factor receptor
| EGFR | ||
|---|---|---|
| Location (UCSC) | Chr 7: 55.02 – 55.21 Mb | Chr 11: 16.75 – 16.92 Mb |
| PubMed search | ||
| Wikidata | ||
| View/Edit Human View/Edit Mouse |