How does inhaled tobramycin work?
Tobramycin inhalation solution works by stopping the growth of a certain bacteria (Pseudomonas aeruginosa) that commonly infects the lungs of people with cystic fibrosis. This effect decreases lung infections and damage, and helps to improve breathing.
What is the mode of action for tobramycin?
Mechanism of action Tobramycin works by binding to a site on the bacterial 30S and 50S ribosome, preventing formation of the 70S complex. As a result, mRNA cannot be translated into protein, and cell death ensues.
What are the broad and specific mechanisms of action for tobramycin?
Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and interferes with the initiation complex between messenger RNA and the 30S subunit, thereby inhibiting initiation of protein synthesis, consequently leading to bacterial …
How does tobramycin work to stop bacteria?
TOBRAMYCIN AN contains an antibacterial agent, tobramycin, which is active against a common lung infection that occurs in patients with cystic fibrosis (CF). Tobramycin belongs to a class of antibiotics called aminoglycosides. It works by killing or stopping the growth of the bacteria that cause the infection.
How is tobramycin injection prepared for inhalation?
Dilute the amount of Tobramycin with enough 0.9% sodium chloride or sterile water to give a total volume of 3 mL in your nebulizer cup. (You will need 1 mL) Inhale the Tobramycin mixture by aerosol nebulizer over a period of about 20 minutes, according to the directions from your doctor.
What does inhaled tobramycin treat?
Tobramycin inhalation is used to treat lung infections in patients with cystic fibrosis. It is breathed into the lungs through the mouth to treat infections caused by the Pseudomonas aeruginosa bacteria.
Are tobramycin and neomycin related?
Cross-reactivity between neomycin and tobramycin relates to similar chemical structures (deoxyinosine of tobramycin and neosamine of neomycin) and is seen in up to 65% of neomycin-allergic patients. Gentamicin and kanamycin are also known neomycin cross-reactors.
Can you use tobramycin and erythromycin together?
No interactions were found between erythromycin and tobramycin. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Why is tobramycin inhaled?
Can tobramycin cause shortness of breath?
Tobramycin inhalation side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.