Who plasma myeloma criteria?
Minimal criteria for the diagnosis of multiple myeloma include the presence of at least 10% abnormal plasma cells in the bone marrow or histologic proof of a plasmacytoma, the usual clinical features of multiple myeloma, and at least one of the following abnormalities: monoclonal serum protein (usually greater than 3 g …
What are the CD markers for multiple myeloma?
The antigens commonly used for plasma cell identification, such as CD38 and CD138, are similarly expressed PCL and multiple myeloma. However, PCL cells are more likely to express CD20 and usually tend to be negative for CD56, CD117 and HLA-DR.
What is plasmablastic morphology?
Plasmablastic morphology was considered to be present (plasmablastic myeloma) when 2% or more plasmablasts were present in the plasma-cell population. Results: Patients underwent transplantation 5 to 88 months (median, 20 months) after the initial diagnosis of myeloma.
What are the crab criteria?
The CRAB criteria consist of end-organ damage with hypercalcaemia, renal dysfunction, anaemia and bone involvement. The CRAB criteria are not pathognomonic of multiple myeloma, and in the appropriate clinical scenario, lymphoma is a possible diagnosis.
How do you identify a plasma cell?
Instead, plasma cells are identified through flow cytometry by their additional expression of CD138, CD78, and the Interleukin-6 receptor. In humans, CD27 is a good marker for plasma cells; naïve B cells are CD27-, memory B-cells are CD27+ and plasma cells are CD27++.
What lab values indicate multiple myeloma?
Calcium: A high level of calcium suggests active reabsorption of bone and thus active myeloma. Lactate dehydrogenase (LDH): A high level of this enzyme may indicate active myeloma. Blood urea nitrogen (BUN) and creatinine: These are indicators of kidney function.
What are the criteria for plasma cell myeloma?
>10% clonal plasma cells in marrow. Must not have characteristic clinical complications or end organ/tissue damage. Symptomatic myeloma requires any level of evidence of clonality plus characteristic complications Any level of clonal bone marrow plasma cells (usually >10%) OR.
What are the criteria for smoldering multiple myeloma?
Definition. Smoldering Multiple Myeloma. Both criteria must be met: Serum monoclonal protein (IgG or IgA) ≥ 30g/L or urinary monoclonal protein ≥ 500mg per 24h and/or clonal bone marrow plasma cells 10-60%. Absence of myeloma-defining events or amyloidosis.
What does it mean to have multiple myeloma?
Multiple myeloma is a cancer of the bone marrow plasma cells. It is synonymous with “myeloma” and “plasma cell myeloma.”. Plasma cells make antibodies against infectious agents such as viruses and bacteria. A cancerous or malignant plasma cell is called a myeloma cell.
What are the IMWG criteria for multiple myeloma?
The revised IMWG criteria allow, in addition to the classic CRAB features, three myeloma defining events (MDEs). The presence of at least one of these markers is considered sufficient for a diagnosis of multiple myeloma, regardless of the presence or absence of symptoms or CRAB features.