What does MMP-2 do?
The MMP2 gene provides instructions for making an enzyme called matrix metallopeptidase 2. This enzyme is produced in cells throughout the body and becomes part of the extracellular matrix, which is an intricate lattice of proteins and other molecules that forms in the spaces between cells.
What is MMP-2 test?
MMP-2 in serum is quantitated using an ELISA (Enzyme linked immunosorbent assay) procedure. It is a two-step sandwich-type immunoassay using two antibodies to MMP-2; monoclonal antibody is the capture antibody and signal polyclonal antibody is conjugated with horse-raddish peroxidase (HRP).
What does MMP-9 stand for?
Matrix metalloproteinase (MMP)-9, one of the most widely investigated MMPs, regulates pathological remodeling processes that involve inflammation and fibrosis in cardiovascular disease. MMP-9 directly degrades extracellular matrix (ECM) proteins and activates cytokines and chemokines to regulate tissue remodeling.
What MMP stand for?
Mixed Member Proportional
Definition. MMP. Mitochondrial Membrane Potential. MMP. Mixed Member Proportional (New Zealand electoral system)
What is the role of MMPs?
Matrix metalloproteinases (MMPs), a group of zinc-dependent endopeptidases involved in the degradation of the extracellular matrix, play an important role in tissue remodeling associated with various physiological processes such as morphogenesis, angiogenesis, and tissue repair, as well as pathological processes …
What is MMP3 enzyme?
Stromelysin-1 also known as matrix metalloproteinase-3 (MMP-3) is an enzyme that in humans is encoded by the MMP3 gene. The MMP3 gene is part of a cluster of MMP genes which localize to chromosome 11q22. MMP-3 has an estimated molecular weight of 54 kDa.
How is MMP-2 activated?
Activation. Activation of MMP-2 requires proteolytic processing. A complex of membrane type 1 MMP (MT1-MMP/MMP14) and tissue inhibitor of metalloproteinase 2 recruits pro-MMP 2 from the extracellular milieu to the cell surface. Activation then requires an active molecule of MT1-MMP and auto catalytic cleavage.
Where is the MMP2 gene located on the chromosome?
72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. The MMP2 gene is located on chromosome 16 at position 12.2.
Where is MMP-2 found in the body?
MMP-2 (matrix metalloproteinase 2), also known as Gelatinase A, is upregulated at sites of tissue damage, inflammation, and in stromal cells surrounding the invading front of metastatic tumors.
What is the role of MMP2 in endometrial breakdown?
The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. The role of MMP2 in lymphangiogenesis was considered in a modelling and theoretical study; MMP2 degrades collagen I to switch on different patterning mechanisms for VEGFC. Activation of MMP-2 requires proteolytic processing.
What kind of diseases are associated with MMP-2?
Activity of MMP-2 relative to the other gelatinase ( MMP-9) has been associated with severity of chronic airway diseases including Idiopathic interstitial pneumonia and Bronchiectasis.