What is CD30 antibody?
CD30 antibody [Ki-1] is expressed in mononuclear Hodgkin’s and multinucleated Reed-Sternberg cells in Hodgkin’s disease, in tumor cells of a majority of anaplastic large cell lymphomas, in a varying proportion of activated T and B cells and by embryonal carcinomas.
What is CD30 a marker for?
CD30 is the characteristic marker of classical Hodgkin lymphoma, anaplastic large-cell lymphoma, and embryonal cell carcinoma, and it is expressed on a subset of aggressive T- and B-cell neoplasms. Its restricted expression on normal cells makes it an attractive candidate for targeted therapy.
Where is CD30 found?
A protein found on some T cells and B cells (two types of white blood cells). It is a receptor for a protein called tumor necrosis factor, which is involved in cell growth and cell survival. The CD30 protein may be found in higher than normal amounts on some types of cancer cells, including lymphoma cells.
Is CD30 an antigen?
CD30 antigen, a member of the tumor necrosis factor (TNF) receptor superfamily, 1-3 was originally identified as a cell surface antigen on primary and cultured Hodgkin’s and Reed-Sternberg cells by use of the monoclonal antibody Ki-1.
What does CD30 positive mean?
CD30-positive cells characterize lymphomatoid papulosis and anaplastic large cell lymphoma but can also be found in nonneoplastic skin disorders. Purportedly, CD30 is useful in the differential diagnosis between insect bites and lymphomatoid papulosis.
What is CD30 test?
CD30 is a member of the tumor necrosis factor receptor (TNF-R) superfamily. Expression of CD30 can also be seen in embryonal carcinomas, malignant melanomas, mesenchymal tumors, and activated T and B lymphocytes and plasma cells.
What is the treatment for lymphoproliferative disorder?
Treatment for lymphoproliferative can include medication, chemotherapy, immunoglobulin therapy, home-based therapies or a bone marrow transplant. The type of therapy chosen for your child will depend on the type of lymphoproliferative disorder and the health of your child.
What does lymphomatoid papulosis look like?
WHAT DOES LYMPHOMATOID PAPULOSIS LOOK LIKE? LyP is characterized by pink or red-brown bumps, that may ulcerate, and can affect any area of the body. LyP lesions typically heal with scaling and crusting, and in some instances, scarring. Lesions usually heal over 2-3 weeks but may take as long as 8 weeks.
How do you treat primary cutaneous anaplastic large cell lymphoma?
HOW IS PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA TREATED? There are many options for treating PCALCL available, but localized treatment with either radiation therapy or surgical excision are the preferred therapies for single lesions of PCALCL.
What are CD30 positive cells?
Which is the ligand of the CD30 receptor?
CD30 receptor is an inducible costimulatory receptor expressed on activated and memory T cells following TCR/CD28 or IL-4 stimulation. The ligand of CD30 is CD30L, which is expressed on activated T cells, as well as on macrophages, DCs, and B cells.
What does CD30 stand for in medical terms?
Freebase(0.00 / 0 votes)Rate this definition: CD30. CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. This receptor is expressed by activated, but not by resting, T and B cells.
How is CD30 expressed in reactive lymphoma cells?
CD30 is an activation antigen and is expressed in a variable number of immunoblasts in reactive lymph nodes, such as in EBV infection (infectious mononucleosis) CD30 expression is present on tumor cells of most classical Hodgkin lymphomas and in some DLBCLs; these tumors are PAX5 positive, whereas ALCL is not
Where is CD30 expressed in the TNFR family?
CD30, a member of the TNFR family, is expressed on activated T cells, NK cells, and B cells. Its ligand, CD30L (CD153), is expressed on activated T cells, resting B cells, and macrophages.