What does interleukin-7 receptor do?
In early blood-forming cells, signaling through the IL-7 receptor ensures the development of mature B cells and T cells. IL-7 receptor signaling also stimulates the later growth and division (proliferation) and survival of these cells.
Is IL-7 inflammatory?
IL-7 promotes inflammation in part via activation of monocytes and macrophages [25] and induces proinflammatory cytokines and chemokines.
Where is IL-7 produced?
Indeed, IL-7 was considered an important factor for the development of T cells long before its role in effector functions was examined. IL-7 is mainly produced in primary lymphoid tissues such as the bone marrow and thymic stromal cells where immune cell development occurs (26, 85).
Is IL-7 a transcription factor?
The Il7r gene is expressed specifically in the immune system in a developmental stage-specific manner. It is not known how the Il7r gene is transcriptionally regulated during B cell development.
Is CD4 T cell receptor?
CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells. These signals lead to the activation of transcription factors, including NF-κB, NFAT, AP-1, to promote T cell activation.
How is interleukin 7 manufactured?
Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells, but is not produced by normal lymphocytes.
What produces il9?
IL-9 is produced by activated Th2 cells, mast cells, and eosinophils. Recently, a new subset of Th cells, termed Th9, has been proposed. These cells have been shown to not only secrete IL-9 but also to enhance inflammatory responses.
What are interleukin drugs?
Interleukin inhibitors are used to treat various inflammatory and autoimmune diseases. Interleukin inhibitors work by targeting cytokines that act as chemical signals between the white blood cells in response to an invading infection.