Who was the BTK Killer and what did he do?
From 1974 to 1991, serial killer Dennis Rader murdered 10 people under the moniker BTK Killer, standing for “Bind, Torture, Kill.” Around his hometown of Wichita, Kansas, Rader was known as a family man and church leader, and no one suspected he was the man sending taunting letters to police and media detailing his brutal, twisted crimes.
Who was Dennis Rader in the BTK case?
The Grisly Story Of Dennis Rader, The Man No One Suspected Was The BTK Killer For 30 years, Boy Scout troop leader and church council president Dennis Rader was secretly the BTK murderer — while looking like the perfect family man to the outside world.
When did BTK call Nancy Fox to report her death?
Dennis Rader in court on August 17, 2005. Seeking help from the public, authorities release the recording of BTK’s December 1977 phone call to report the death of Nancy Fox. Tips come pouring in from listeners who think they recognize the voice, though no relevant information emerges.
What was the Barbie doll in the BTK case?
BTK’s Barbie doll. In December 2004, a viewer of KAKE-TV called the station to report a suspicious package in a local park. They recovered a box containing a bound Barbie doll made to mimic the murder of Josephine Otero (she had been hanged from a basement pipe) and Nancy Fox’s driver’s license.
Dennis Rader, who took 10 innocent lives in the area of Wichita, Kansas, as the BTK Killer – for Bind, Torture, Kill – seemingly had his twisted modus operandi figured out to a “T.”
How is BTK used to control the CLL?
They established that twice-daily dosing achieved higher BTK occupancy and resultant downstream pathway inhibition in lymph nodes than once-daily dosing and established the rate of BTK resynthesis in CLL cells.
What’s the half life of a BTK inhibitor?
Although all 3 FDA-approved BTK inhibitors, ibrutinib, acalabrutinib, and zanubrutinib, have short plasma half-lives (2 to 3 hours, 1 hour, and 4 hours, respectively), they have sustained biologic activity due to covalent binding to BTK. 5-7
How does acalabrutinib affect BTK in blood?
The pharmacokinetic properties of acalabrutinib, with a half-life of ∼1 hour and irreversible inhibition of BTK, mean that decline in BTK occupancy from drug peak to trough represents resynthesis of BTK within CLL cells, occurring at a time when there is no significant quantity of free drug remaining in plasma.