What is the typical CLL Immunophenotype?
The typical CLL phenotype is CD5+, CD23+, FMC7-, weak expression of surface Ig (sIg) and weak or absent expression of membrane CD22 and CD79b.
What is the immunophenotype of the abnormal lymphocyte in CLL?
Conclusion: Our results have shown that characteristic immunophenotype which differentiates CLL from other MBCN is defined by following marker combination–CD19+ CD20(+Iow) CD22(+low) CD5(+high) CD23+ FMC7-CD79b(+Iow) sIg(+Iow). CLL score values of 5 or 4 points are highly suggestive for diagnosis of CLL.
What is the correct total WBC count?
Normal Results The normal number of WBCs in the blood is 4,500 to 11,000 WBCs per microliter (4.5 to 11.0 × 109/L).
What labs are abnormal with CLL?
People with CLL have too many lymphocytes. (This may be called lymphocytosis.) Having more than 10,000 lymphocytes/mm³ (per cubic millimeter) of blood strongly suggests CLL, but other tests are needed to know for sure. You might also have low levels of red blood cells and platelets.
Does CLL cause high WBC?
People with CLL may have very high white blood cell counts because of excess numbers of lymphocytes (lymphocytosis), but the leukemia cells don’t fight infection the way normal white blood cells do.
What does moderate smudge cells mean?
Smudge cells are remnants of cells that lack any identifiable cytoplasmic membrane or nuclear structure. Smudge cells, also called basket cells, are most often associated with abnormally fragile lymphocytes in disorders such as chronic lymphocytic leukemia (CLL).
What FMC 7?
FMC7 is a transmembrane glycoprotein with a molecular weight of 105 kDa. This antigen was described as a particular conformation of a surface protein encoded by the CD20 gene. FMC7 antibody reactivity to its particular CD20 epitope was found to be dependent of membrane cholesterol level.