What is the thymidylate synthase gene?
TYMS (Thymidylate Synthetase) is a Protein Coding gene. Diseases associated with TYMS include Mucositis and Rectum Cancer. Among its related pathways are Cell Cycle, Mitotic and Mitotic G1-G1/S phases. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and mRNA binding.
What does a thymidylate synthase do?
Thymidylate synthase plays a central role in the biosynthesis of thymidylate, an essential precursor for DNA biosynthesis. In addition to its role in catalysis and cellular metabolism, studies from our laboratory have shown that thymidylate synthase functions as an RNA binding protein.
Where thymidylate synthase?
Thymidylate synthase (TS) (EC 2.1….Thymidylate synthase.
| TYMS | ||
|---|---|---|
| Location (UCSC) | Chr 18: 0.66 – 0.67 Mb | Chr 5: 30.06 – 30.07 Mb |
| PubMed search | ||
| Wikidata | ||
| View/Edit Human View/Edit Mouse |
How do you find the base sequence of a gene?
How to: Find transcript sequences for a gene
- Search the Gene database with the gene name, symbol.
- Click on the desired gene.
- Click on Reference Sequences in the Table of Contents at the upper right of the gene record.
Why is finding ORFs helpful in determining the gene number in an unknown sequence?
Why is finding ORFs helpful in determining the gene number in an unknown sequence? -Open reading frames never occur randomly. A random sequence is expected have a stop codon every 20 codons. To estimate the number of genes in a DNA sequence, stretches of nucleotide codons without stop codons are found using a computer.
How do you know what known sequence of DNA was closest to your unknown sequence?
You can evaluate the level of similarity by looking at the scores to the left of each result description. The result with the highest “Max score” and “Total score” will be the most similar to your unknown sequence.
How is thymidylate synthase related to pancreatic cancer?
Polymorphisms and haplotype structure of the human thymidylate synthase gene is associated with response to therapy in pancreatic cancer. Thymidylate synthase and p53 positivity was significantly associated with the failure of FEC treatment. High thymidylate synthase expression is associated with gastric cancer.
What is the role of thymidylate synthase in DNA synthesis?
“Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme.” “Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.” Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
How is thymidylate synthase ( TS ) expression related to OS?
Thymidylate synthase (TS) expression was positively correlated with lymphatic metastasis and negatively correlated with the overall survival (OS) in pancreatic ductal adenocarcinoma (PDA) patients.
How are dihydrofolate reductase and thymidylate synthase related?
Dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells. High expression level of TYMS is associated with neuroendocrine lung tumors. This study finds that measurement of tumor levels of thymidylate synthase is not helpful in assigning specific adjuvant treatment for colorectal cancer.