What is the empirical formula for rofecoxib?
The empirical formula for rofecoxib is C17H14O4S, and the molecular weight is 314.36.
Why is rofecoxib banned?
Merck & Co. announced Sept. 30 a voluntary worldwide withdrawal of rofecoxib (Vioxx) after a study showed patients taking the drug on a long-term basis face twice the risk of a heart attack compared with patients receiving placebo.
Is rofecoxib banned in India?
NEW DELHI: Arthritis drugs Rofecoxib and Valdecoxib, both of which are globally banned, are openly available at many chemist shops across the Capital. These drugs, widely used by arthritis patients needing anti-inflammatory painkillers, are also banned in India.
What is the molecular formula of Vioxx?
C17H14O4S
Rofecoxib/Formula
Why did Vioxx cause heart attacks?
Using mice, the researchers found that Vioxx caused a big jump in a substance — a fat — that could contribute to heart attacks and strokes. The substance, called 20-hydroxyeicosatetrasanoic acid, or 20-HETE, which can constrict blood vessels in the heart and brain and increased blood clotting.
Is rofecoxib approved by the FDA?
Rofecoxib was approved by the FDA to treat osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, acute pain conditions, migraine, and dysmenorrhea.
Was Bextra approved by the FDA?
FDA approved BEXTRA (valdecoxib) 10 mg and 20 mg Tablets on November 16, 2001. BEXTRA is indicated for relief of the signs and symptoms of osteoarthritis and adult rheumatoid arthritis and for the treatment of primary dysmenorrhea.
Why rofecoxib was withdrawn from the market of many countries?
Worldwide, over 80 million people were prescribed rofecoxib at some time. In September 2004, Merck voluntarily withdrew rofecoxib from the market because of concerns about increased risk of heart attack and stroke associated with long-term, high-dosage use.
What was the problem with Vioxx?
Vioxx: The Downfall of a Drug Merck removed one of the world’s best-selling painkillers from the market in 2004 after a study showed Vioxx caused an increased risk of serious cardiovascular events, such as stroke and heart attack.
What problems did Vioxx cause?
The empirical formula for rofecoxib is C 17 H 14 O 4 S, and it has the following chemical structure: Rofecoxib is a white to off-white to light yellow powder.
What is the chemical structure of Vioxx ( rofecoxib )?
VIOXX® (rofecoxib) is a nonsteroidal anti-inflammatory drug (NSAID). The chemical name is 4- [4 (methylsulfonyl)phenyl]-3-phenyl-2 (5H)-furanone. The molecular weight is 314.36. The empirical formula for rofecoxib is C 17 H 14 O 4 S, and it has the following chemical structure:
Is there a cardiovascular risk to taking rofecoxib?
In studies sponsored by Merck no cardiovascular risk for rofecoxib emerges (13, 14). both rofecoxib and celecoxib (15). Analysing data of more than 150.000 infarction in patients taking rofecoxib (16). Ray et al. found a tha 25 mg/d of rofecoxib (17). No similiar results were published for celecoxib.
What is the phenyl group of rofecoxib?
Rofecoxib is a butenolide that is furan-2 (5H)-one substituted by a phenyl group at position 3 and by a p- (methylsulfonyl)phenyl group at position 4.