What is plasma cell granuloma?
Plasma cell granuloma is a rare benign lesion characterized by the infiltration of plasma cells; primarily occurring in the lungs. It is also seen to occur in the brain, kidney stomach, heart, and so on. In the intraoral region it is seen to involve the tongue, oral mucosa, and gingiva.
Do granulomas have plasma cells?
Gingival Plasma cell granulomas are extremely rare. These are non-neoplastic, tumor-like lesions of unknown etiology and are composed predominantly of polyclonal plasma cells.
What are rare plasma cells?
Plasma cell leukaemia (PCL) is a very rare plasma cell dyscrasia with a significant number of monoclonal plasma cells in the peripheral blood. It is diagnosed by the presence of ≥ 2×109 /L plasma cells in the blood or by plasma cells making up ≥20% of the leukocyte count.
What do plasma cells indicate?
Plasma cells are differentiated B-lymphocyte white blood cells capable of secreting immunoglobulin, or antibody. These cells play a significant role in the adaptive immune response, namely, being the main cells responsible for humoral immunity.
What are the symptoms of Plasmacytoma?
Extramedullary plasmacytoma
- Headache.
- Nasal discharge.
- Epistaxis.
- Nasal obstruction.
- Sore throat.
- Hoarseness.
- Dysphonia.
- Dysphagia.
Does myeloma affect the brain?
Myeloma and myeloma treatments can affect the brain’s ability to collect, retain and process information. ‘Chemo brain’ is a term used to describe the mind and memory issues cancer patients can experience. Your healthcare team may refer to these symptoms as cancer-related cognitive changes.
How long do plasma cells live?
Plasma cells can be generally divided into two distinct categories based on their lifespan: (a) short-lived plasma cells/plasmablasts (proliferating cells with a life span of 3–5 days) and (b) long-lived plasma cells (non-proliferating cells with a life span of several months to lifetime).
What diseases are associated with plasma?
Multiple myeloma, Waldenström macroglobulinemia, POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome, and AL amyloidosis (immunoglobulin light chain amyloidosis) are examples of malignant plasma cell disorders which require treatment.