What is papillary proliferation?
Papillary proliferation of the endometrium is an unusual lesion that is composed of papillae with fibrovascular stromal cores covered with benign-appearing glandular epithelium. We studied the clinicopathological and immunohistochemical features of four cases of endometrial papillary proliferations.
What is papillary changes?
Papillary apocrine change is a rare condition that involves the cells lining the inside of the breast duct (epithelium). There is an overgrowth of cells that have “apocrine” features, meaning that the gel-like substance that fills the cell (called cytoplasm) is grainy.
Is proliferative phase endometrium normal?
Proliferative endometrium is a very common non-cancerous change that develops in the tissue lining the inside of the uterus. It is a normal finding in women of reproductive age. During the menstrual cycle, the endometrium grows under the influence of two major hormones – estrogen and progesterone.
Which hormone is responsible for proliferation of the endometrium?
estrogen
During the proliferative or follicular phase (4th to 14th day) the secretion of estrogen through the growing ovarian follicle is responsible for the proliferation of the endometrium (intensive mitosis in the glandular epithelium and in the stroma).
What is cytologic atypia?
Cytologic atypia is defined by the presence of nuclei that are large, regularly shaped and hyperchromic, at times showing binucleation and dyskeratosis and presenting with absence of a perinuclear halo. Cytologic atypia can also be found in metaplastic cells.
What is a papillary pattern?
Papillary is a word pathologists use to describe cells that are sticking together to create long finger-like projections of tissue. The cells are seen on the outside surface of the tissue while small blood vessels are seen on the inside. The word micropapillary is used similarly to describe very small projections.
What causes proliferation of the endometrium?
Proliferative endometrium stage The term “proliferative” means that cells are multiplying and spreading. During this phase, your estrogen levels rise. This causes your endometrium to thicken. Your ovaries also prepare an egg for release.
What is Decidualization endometrium?
Decidualization refers to the functional and morphological changes that occur within the endometrium to form the decidual lining into which the blastocyst implants. These changes include the recruitment of leukocytes and, importantly, the differentiation of endometrial stromal fibroblast cells (ESCs) into DSCs.
Does progesterone maintain the endometrium?
Progesterone then prepares the tissue lining of the uterus to allow the fertilised egg to implant and helps to maintain the endometrium throughout pregnancy.
Is cytology the same as pathology?
Is cytology part of pathology? Cytology (cytopathology) is a branch, or subspecialty, of pathology. In medicine, pathology deals with the laboratory examination of cells in samples of body tissue or fluids for diagnostic purposes.
Are there any cases of papillary proliferation without cytologic atypia?
Papillary proliferation of the endometrium: a clinicopathologic study of 59 cases of simple and complex papillae without cytologic atypia Papillary proliferation of the endometrium (PPE) without cytologic atypia is uncommon and has only been studied in detail by Lehman and Hart in 2001.
What is papillary proliferation of the endometrium ( PPE )?
Papillary proliferation of the endometrium (PPE) without cytologic atypia is uncommon and has only been studied in detail by Lehman and Hart in 2001. On histologic examination, PPE ranges from simple papillae with fibrovascular cores, often involving the surface of endometrial polyps, to complex int …
What is a simple proliferation of the endometrium?
Simple papillae were defined as those with short, predominantly nonbranching stalks; those with occasional secondary branches and/or detached papillae were also included in this group. Localized proliferations were those with 1 or 2 foci involving the surface or the subjacent glands of polyps or nonpolypoid endometrium.
Is there a risk of endometrial carcinoma with complex papillae?
Lesions with architecturally complex papillae, especially when extensive, have an increased risk of concurrent or subsequent endometrial hyperplasia and carcinoma and should probably be regarded as analogous to atypical complex hyperplasia, and the term “complex papillary hyperplasia” is appropriate.