What is formulation of suspension?
FORMULATION OF SUSPENSIONS: Wetting agents: They are added to disperse solids in continuous liquid phase . Thickeners: They are added to increase the viscosity of suspension. ex: gaur gum , xanthan gum. Buffers and pH adjusting agents:They are added to stabilize the suspension to a desired pH range.
What is suspension definition in pharmacy?
A pharmaceutical suspension is a coarse dispersion of insoluble solid particles in a liquid medium. The particle diameter in a suspension is usually greater than 0.5 µm. Suspensions are an important class of pharmaceutical dosage forms.
Why drugs are formulated as suspension?
Substances can be chemically unstable, insoluble in water, distasteful etc. Suspensions are often used as a dosage form when the drug is insoluble in water and when use of solubilizing agents is not possible.
What are the different approaches to the formulation of suspensions?
Formulation of suspension [2] However, there are three common approaches that are applied to formulate a suspension. These are 1) Controlled flocculation, 2) Structured vehicle and 3) Controlled flocculation in the structured vehicle.
What is suspension and properties of suspension?
General Characteristics and Properties of Suspension Suspensions are a heterogeneous mixture of two or more substances. Particles of the solute do not dissolve in the solvent rather they remain suspended in bulk throughout. The size of particles of suspension is large enough to be visible from naked eyes.
What are the types of suspensions in pharmaceutics?
Based on the route of administration, suspensions can be classified as oral, topical, ophthalmic, otic, or nasal suspensions. Each of these present unique challenges and requirements in terms of desired quality attributes.
How do you make a suspension?
Preparation of Suspensions
- Reduce drug powder to desired size.
- Add drug and wetting agent to solution.
- Prepare solution of suspending agent.
- Add other ingredients.
- Homogenize medium.
- Package.
Why do we make suspension?
The reasons for the formulation of a pharmaceutical suspension: — when the drug is insoluble in the delivery vehicle. –To mask the bitter taste of the drug. –To increase drug stability.
Which suspending agent is used in the formulation of suspension?
Xanthan gum in drug delivery applications XG is widely used as a suspending agent and stabilizer in suspension due to its safety properties in food and drug applications.
What are the characteristics of suspension?
Properties of Suspension
- A suspension is a heterogeneous mixture.
- The size of solute particles in a suspension is quite large.
- The particles of a suspension can be seen easily.
- The particles of a suspension do not pass through a filter paper.
- The suspension is unstable.
What are the 4 types of suspension?
Modern springing systems are based on four basic designs. Get to know these four spring classes: leaf springs, coil springs, torsion bars, and air springs.
What is the definition of a pharmaceutical suspension?
Vignan Pharmacy College 5 Definition A Pharmaceutical suspension is a coarse dispersion in which internal phase (therapeutically active ingredient) is dispersed uniformly throughout the external phase.
How is the formulation of a suspension Done?
Formulation of Suspension General Procedure • First the particle size is reduced to a desired size with the help of mill or other equipments. • The insoluble materials are levigated or grinded to a smooth paste with a vehicle containing the wetting agent.
Why are suspensions and emulsions unique dosage forms?
Formulation of Suspensions Biphasic liquids such as suspensions and emulsions are unique dosage forms because many of their properties are due to the presence of a boundary region between two phases. In suspensions, a liquid and an insoluble solid meet to form an interface.
How are suspensions classified according to their concentration?
Classification of suspension based on the concentration of the dispersed phase Based on the concentration of the dispersed phase, suspensions can be classified as dilute and concentrated suspension.