What is cyclodextrin inclusion complex?
Cyclodextrin (CD) are cyclic oligosaccharides consisting of glucopyranosyl units linked by α-(1,4) bonds. The cyclodextrin molecules have a unique structure with a hydrophobic cavity and a hydrophilic surface which can form inclusion complex with a wide variety of guests.
What are inclusion complexes?
Inclusion complexes are molecular compounds having the characteristic structure of an adduct, in which one compound (host molecule) spatially encloses another. The resulting inclusion compounds belong to the type of “host-guest” complexes.
What is the beta cyclodextrin?
β-Cyclodextrin is a cyclic derivative of starch prepared from partially hydrolyzed starch (maltodextrin) by an enzymatic process. Cyclodextrin is dissolved in water to form an aqueous solution, and the core compound is added to form an inclusion complex in crystalline form.
What are the advantages properties of cyclodextrin inclusion complexes?
Cyclodextrins and their derivatives have the ability to encapsulate the bioactive compounds into its cavity and protect these from the environmental conditions, improve the solubility, bioavailability, and other properties also.
Which is the example of inclusion complex?
An example of supramolecular self-assembly is host-guest inclusion complexes made of cyclodextrins (CDs) and guest molecules. CDs are macrocyclic oligosaccharides composed of 6, 7 or 8 D(+)-glucose units linked by α-1,4-linkages and named α-, β- or γ- CD, respectively.
Can a cyclodextrin cavity form an inclusion complex?
Cyclodextrin can form inclusion complex with a wide variety of solid, liquid and gaseous compounds. Complex formation is a dimensional, geometrically limited fit, between cyclodextrin cavity and the guest molecule [2].
What makes beta cyclodextrin a stable oligosaccharide?
Beta-cyclodextrin, a cyclic oligosaccharide consisting of seven glucose units joined as α- (1→4) isomers, forms a stable insoluble inclusion complex with cholesterol and is nontoxic, edible, nonhygroscopic, stable chemically and easily separable.
Which is more affinity for β cyclodextrin?
In general, flavors exhibit more affinity for β-cyclodextrin ( Đorđević et al., 2014 ). The external part of the cyclodextrin molecule is hydrophilic, whereas the internal part is hydrophobic. The guest molecules, which are apolar, can be entrapped in the apolar internal cavity by hydrophobic interaction.
How is excess guest removed from cyclodextrin complex?
Excess quantity of guest melted, mixed with powdered cyclodextrin, after cooling excess quantity of quest is removed by washing with weak complex forming solvent. The method restricted to sublimable guest like menthol. III. Solution-enhanced dispersion by the Supercritical fluids (SEDS)