What is Coelomic metaplasia?
The Coelomic metaplasia theory postulates that endometriosis originates from the metaplasia of specialised cells that are present in the mesothelial lining of the visceral and abdominal peritoneum [27.
What is metaplasia theory?
The metaplastic theory suggests that pelvic endometriosis may be derived through the metaplastic transformation of peritoneal meso- thelium. Initial morphologic observations have confirmed that en- dometriosis may manifest as a serial change from the adjacent meso- thelial cells.
What is the induction theory in endometriosis?
The induction theory states that unknown substances released from shed endometrium induce undifferentiated mesenchyma to form endometriotic tissue. Regardless of which theory is correct, additional factors may be responsible for the expression of the disease.
Where is Coelomic epithelium located?
The coelomic epithelium develops into: peritoneum, pleura and the surface of the ovary. This combines retrograde and metaplasia and can explain the distant sites of endometriosis.
What is Coelomic?
The coelom (or celom) is the main body cavity in most animals and is positioned inside the body to surround and contain the digestive tract and other organs. In some animals, it is lined with mesothelium. In other animals, such as molluscs, it remains undifferentiated.
What are the complications of endometriosis?
What are complications of endometriosis?
- Infertility/subfertility.
- Chronic pelvic pain and subsequent disability.
- Anatomic disruption of involved organ systems (eg, adhesions, ruptured cysts)
What is the most common site of endometriosis?
The most common sites of endometriosis include:
- The ovaries.
- The fallopian tubes.
- Ligaments that support the uterus (uterosacral ligaments)
- The posterior cul-de-sac, i.e., the space between the uterus and rectum.
- The anterior cul-de-sac, i.e., the space between the uterus and bladder.
- The outer surface of the uterus.
What is the most widely accepted theory about the origin of endometriosis?
In conclusion, the transplantation theory (suggesting the implantation and subsequent growth of retrogradely-shed viable endometrial cells) still remains the most widely-accepted theory to explain the pathogenesis of endometriosis, although the development of endometriosis is probably a multifactorial event.
Is Coelomic epithelium mesoderm?
The coelomic epithelium is a single layer of cells which covers the entire coelomic cavity including the gonadal primordium….Developmental Ontology of. Coelomic Epithelial Cells.
| Name | Anatomical Compartment | Code |
|---|---|---|
| Intermediate Mesoderm Cells | Intermediate Mesoderm | InMCs |
What is the coelomic cavity?
The coelom (or celom) is the main body cavity in most animals and is positioned inside the body to surround and contain the digestive tract and other organs. In some animals, it is lined with mesothelium.
Is there evidence for coelomic metaplasia in endometriosis?
Coelomic metaplasia theory of endometriosis: evidence from in vivo studies and an in vitro experimental model
Is the coelomic epithelium the origin of endometriosis?
An alternative hypothesis, historically attributed to Meyer, 23 suggests that metaplasia of the coelomic epithelium is the origin of endometriosis. This theory is logical, because cells from both the peritoneum and endometrium derive from a common embryologic precursor: the coelomic cell.
What kind of cancer is found in coelomic epithelium?
Cancer antigen 125 (CA-125) is a well-established tumor marker yielded in coelomic epithelia during embryonic development. It is often used in the diagnosis of ovarian cancer, but it can also be altered in endometriosis.
Is the coelomic epithelium a type 1 or Type 2 receptor?
Human ovarian epithelium derives from the coelomic epithelium, which expresses both type I and type II receptors, suggesting MIS as a potential therapeutic for the most common ovarian cancers that originate from these cells.