What is a replicon assay?
The replicon cell culture system is used to identify small molecules with the potential to inhibit HCV RNA replication. The replicon system has also been used to elucidate inhibitors’ antiviral mechanism of action and to optimize antiviral potency.
What is replicon system?
A viral replicon is a self-replicating sub-genomic viral RNA originated from viral genome, which contains viral non-structural genes that are critical for viral genome replication with structural proteins deleted or replaced by foreign genes.
What is HCV genotype 3b?
Genotype 3 represents a unique entity within HCV treatment. It is associated with genotype specific mechanisms of steatosis in addition to accelerated development of fibrosis and higher rates of hepatocellular carcinoma. These findings underscore the need for effective therapy for this group of patients.
What happens if HCV is positive?
A positive result means that you were exposed to the hepatitis C virus at some point in your life. If the result is positive, your provider will perform a second test called hepatitis C virus RNA (or HCV RNA) to see if the virus is still in your body.
What is a replicon in DNA?
A segment of the eukaryotic genome that contains several genes and is replicated as a unit from a single origin. replication is bi-directional; its boundaries are the points where replication from one origin meets the replication fork which advances from the opposite direction.
How does a replicon work?
Each employee enters the hours they work in their timesheet, and then they submit it at the end of each timesheet period. They can enter time against available projects, tasks, or activities, and can record comments. In addition, they can complete custom fields and copy data from previous timesheets.
What is replicon used for?
To ensure data is error-free and is ready for processing, Replicon timesheet software helps to verify, cleanse, analyze, review, and apply the right workflows to your time information, and provides a built-in compliance and rules engine to adhere to key business policies.
What does genotype 1b mean?
Conclusion: HCV genotype 1b is associated with a statistically significant higher risk of developing HCC. Patients with cirrhosis that are infected with this genotype require more intensive surveillance for the early detection and aggressive management of neoplasia.
How do you treat Hep C positive?
Hepatitis C infection is treated with antiviral medications intended to clear the virus from your body. The goal of treatment is to have no hepatitis C virus detected in your body at least 12 weeks after you complete treatment.
Can you live a normal life with Hep C?
Outlook. The prognosis of chronic HCV is typically very good, and as treatment continues to improve, it will only get better. Most people with chronic HCV can live a normal life, providing that doctors are able to diagnose it before any liver damage or other complications occur.
What is replicon and its significance?
It is critical that all the DNA in a cell be replicated once, and only once, per cell cycle. Jacob, Brenner and Cuzin defined a replicon as the unit in which the cell controls individual acts of replication. The replicon initiates and completes synthesis once per cell cycle.