What are quinazoline derivatives?
CEP-32496. The quinazoline derivative CEP-32496 is a novel, orally active BRAF inhibitor identified to be highly effective against the proliferation of multiple BRAF(V600E)-dependent cancer cell lines and BRAF(V600E)-dependent xenograft mouse models of human colorectal cancer [82, 83].
What is quinazoline used for?
One of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and analgesic activities.
Who discovered quinazoline?
The synthesis of quinazoline was first reported in 1895 by August Bischler and Lang through the decarboxylation of the 2-carboxy derivative (quinazoline-2-carboxylic acid).
What is Quinazoline ring?
Quinazoline is a heterocyclic compound of two fused six-membered simple aromatic rings—benzene and pyrimidine ring. It is a yellow-colored compound, found usually in crystalline form.
What are the substitution patterns for quinazoline derivatives?
Synthesis of quinazoline and quinazolinone derivatives substitution patterns of the 1,3-diazine moiety of the system. The first quinazoline reaction of cyanogens with anthranilic acid [15]. Many years later quinazoline was can be synthesized more easily by a different method. From anthranilic acid and formamide. phosphorus trichloride in toluene.
Which is a high yield form of quinazoline?
Oxidation of quinazoline in dilute aqueous acid, with two equivalents of hydrogen peroxide at room temperature gave a high yield of 3,4- dihydro-4-oxo quinazoline. 4 furnished a high yield of 3,4- dihydro-4-oxo quinazoline was also formed.
Where does the alkylation of quinazoline take place?
Alkylation of quinazoline takes place on N, 3- methyl, 3-ethyl-3-alkyl and 3-benzyl quinazolinium salts readily take up a molecule of alcohol to form the corresponding 4-alkoxy-3-alkyl-3,4-dihydro quinazolinium salts.