Is Lymphomatoid Papulosis a cancer?
While LyP usually is not classified as a cancer (although there has been some debate), it has characteristics of lymphoma under the microscope, and people with LyP have a life-long increased risk of developing lymphoma such as mycosis fungoides, PC-ALCL, or Hodgkin lymphoma.
What are the symptoms of Lymphomatoid Papulosis?
Without treatment, individual bumps will heal in approximately 6 weeks. While healing, the bumps can be painful or itchy. Lymphomatoid papulosis may come and go for months or many years. Although it is a harmless disease of the skin, patients with this condition are at higher risk for types of cancers called lymphomas.
What does Lymphomatoid Papulosis look like?
WHAT DOES LYMPHOMATOID PAPULOSIS LOOK LIKE? LyP is characterized by pink or red-brown bumps, that may ulcerate, and can affect any area of the body. LyP lesions typically heal with scaling and crusting, and in some instances, scarring. Lesions usually heal over 2-3 weeks but may take as long as 8 weeks.
What is CD30-positive?
CD30-positive cells characterize lymphomatoid papulosis and anaplastic large cell lymphoma but can also be found in nonneoplastic skin disorders. Purportedly, CD30 is useful in the differential diagnosis between insect bites and lymphomatoid papulosis.
What is CD30 expression?
CD30 is a member of the tumor necrosis factor receptor superfamily. It is characteristically expressed in certain hematopoietic malignancies, including anaplastic large cell lymphoma and Hodgkin lymphoma, among others.
What is LyP lymphoma?
Lymphomatoid papulosis (LyP) is a chronic papulonecrotic or papulonodular skin disease with histologic features suggestive of a malignant lymphoma. The disease is characterized by recurrent crops of pruritic papules at different stages of development that predominantly arise on the trunk and limbs.
How to tell if you have lymphomatoid papulosis?
Lymphomatoid papulosis (LyP) is a non-contagious, chronic skin condition characterized by the eruption of recurring, self-healing bumps (lesions) on the skin. The lesions typically begin small and then become larger, and they may bleed or ulcerate before becoming scaly and crusty. They often develop a red-brown color.
Is there a cure for lymphomatoid papulosis in the Netherlands?
In their recent publication on their experience with methotrexate in lymphomatoid papulosis, the Dutch Cutaneous Lymphoma Group reported 90% of good to very good results, but less than one-third of patients were able to discontinue treatment following complete and sustainable remission 24). Phototherapy can also be offered.
Is there a life expectancy for lymphomatoid papulosis?
People with lymphomatoid papulosis who do not develop cancer have a normal life expectancy. While there is a substantial risk to develop lymphoma, the reported mortality rates from associated lymphomas are low 11). The cause of lymphomatoid papulosis is unknown.
How is methotrexate used to treat lymphomatoid papulosis?
Used orally, subcutaneously, or intramuscularly, methotrexate is the systemic treatment of choice for lymphomatoid papulosis, regardless of histological type 23). Starting with low doses (7.5 to 10 mg per week) and then increased in increments of 2.5 or 5 mg until remission of the disease is obtained.