Does vancomycin need monitoring?
Vancomycin Monitoring Vancomycin serum concentrations should be checked to optimize therapy and used as a surrogate marker of effectiveness. Trough, rather than peak, levels should be monitored. Trough levels should be checked just before the fourth dose, when steady-state levels are likely to have been achieved.
What lab should be monitored with vancomycin?
patient’s clinical response to vancomycin • CBC at least weekly on long-term vancomycin therapy • SCr at least twice a week initially, then at least weekly on long-term therapy; more frequent monitoring should be considered if renal function changing, if concurrent nephrotoxic drug, underlying renal dysfunction or age …
How often should you check vancomycin levels?
Usually only vancomycin troughs are needed. Random levels may be obtained on patients with poor renal function who only receive intermittent or post-dialysis dosing. At minimum, levels should be obtained for all patients by 72 hours of therapy and at least weekly thereafter.
Why do we check vancomycin levels?
Monitoring the level of vancomycin is important because its effectiveness relies on keeping blood levels above a minimum concentration for the entire duration of therapy (also referred to as total drug exposure).
How do you titrate vancomycin?
- 20-25. Decrease dose by 250-500 mg.
- OR. Increase the dosage interval to the next frequency.
- 25-30. Increase the dosage interval to the next frequency.
- AND/OR. Decrease the dosage by 500 mg.
- HOLD VANCOMYCIN UNTIL LEVEL IS < 20 mcg/mL, then restart a modified regimen.
How do you administer vancomycin?
Vancomycin shall only be administered as slow intravenous infusion of at least one hour duration or at a maximum rate of 10 mg/min (whichever is longer) which is sufficiently diluted (at least 100 ml per 500 mg or at least 200 ml per 1000 mg) (see section 4.4).
When do you check peak and trough?
Peak and trough levels
- A trough level is drawn immediately before the next dose of the drug is administered.
- A peak level is drawn 1 to several hours after the drug is administered (depending on the drug).
What tube is used for Vanco trough?
MUST be collected in a red top tube NO GEL; For the Vancomycin, Total, 2 specimens are required, 1 peak specimen and 1 trough specimen.
When should peak and trough levels be drawn?
A trough level is drawn immediately before the next dose of the drug is administered. A peak level is drawn 1 to several hours after the drug is administered (depending on the drug).
What is trough and peak level?
The trough level is the lowest concentration in the patient’s bloodstream, therefore, the specimen should be collected just prior to administration of the drug. The peak level is the highest concentration of a drug in the patient’s bloodstream.
Why do we monitor peak and trough levels?
Peaks and troughs are the highest and lowest concentrations of a medication in an individual’s body. They are used to determine dosing intervals, or how much time should pass between each new administration of the drug.
What is vancomycin pulse dosing?
These regimens typically include a 10- to 14-day course of oral vancomycin at a dose of 125 mg four times per day, followed by a tapering dose over 2 weeks, followed by “pulsed” dosing with 125 mg once every 2 or 3 days for 2 to 8 weeks (14–16).