Does CD20 internalize?
CD20-targeted therapy by means of anti-CD20 mAb (commercially known as Rituximab, Mabthera) was approved by the US FDA in 1997 for the treatment of non-Hodgkin’s lymphoma. Upon interaction with the anti-CD20 mAb, this receptor does not undergo internalization as compared to other receptors.
What does CD20 positive mean?
CD20 positive t cell lymphoma represents a small fraction of t cell lymphomas. The pathogenesis of CD20+ T cell lymphoma is not known. CD20 is a transmembrane protein that was first identified as a B cell marker in 1980. CD20 appears early in B cell development and remains present through the Plasma Cell stage of development.
What is CD20 therapy?
CD20 is the target for Rituxan, the anti-CD20 molecular targeted therapy for CD20 positive lymphomas. This is a common theranostic use for lymphoma patients, as well as for patients with rheumatoid arthritis.
What is the role of CD20 in immunology?
CD20 is much used as a target for therapeutic monoclonal antibodies in the treatment of B cell malignancies and autoimmune disease. Its exact role in B cell function is not clear although it plays a role in Ca 2+ transport across the plasma membrane.
What are the stages of T cell lymphoma?
Cutaneous T-cell lymphomas (CTCLs) are generally classified into four stages, depending on the extent of spread along the skin and to the lymph nodes, blood, and other organs. In one system, the stages are designated Stage I to IV, with I representing the most localized disease and IV representing the most extensive disease.