Can you recover from leukoencephalopathy?
Acute toxic leukoencephalopathy caused by heroin inhalation can be reversible, with radiologic resolution reported after 7 months. Clinical recovery was not complete with persistent ataxia despite impressive cognitive improvement.
What drugs cause leukoencephalopathy?
Other drugs that have been associated with toxic leukoencephalopathy in much more rare occurrences include psychoactive drug 2C-E (“Europa”), oxycodone, cocaine, and methadone.
What is radiation-induced leukoencephalopathy?
Background: Radiation-induced leukoencephalopathy (RIL) is the most threatening delayed complication of cerebral radiotherapy (RT) and remains roughly defined by cognitive dysfunction associated with diffuse FLAIR MRI white matter hyperintensities after brain irradiation.
Is radiation-induced leukoencephalopathy fatal?
In summary, clinicians should be aware of potential severe radiation-induced leukoencephalopathy after combination WBRT and SRS, which manifested as a fatal complication in our patient with bulky brain metastases.
Can the JC virus go away?
There is no cure once the JC virus enters the brain and causes PML, but if the infection is caught soon enough there are treatments that may reduce the risk of longterm complications.
What does leukoencephalopathy mean?
Leukoencephalopathy (LE) is a structural alteration of the cerebral white matter in which myelin suffers the most damage (Filley & Kleinschmidt-DeMasters, 2001).
Can radiotherapy cause hydrocephalus?
Patients with radiation leukoencephalopathy have the typical clinical syndrome of normal pressure hydrocephalus with cognitive impairment, ataxia, and urinary incontinence.
How is JC virus contracted?
JC virus is spread via the urine-oral route. JC virus remains latent in the kidney epithelium cells, in bone marrow hematopoietic cells, in tonsillar lymphocytes, and in the brain. Although JC virus antibodies are detectable in most individuals, these antibodies cannot control JC virus reactivation and replication.