What is villin Cre?
Also Known As:Villin-cre , 12.4KbVilCre line 997 These Vil1-cre mice express Cre recombinase in villus and crypt epithelial cells of the small and large intestines and may be useful in studies of intestinal organogenesis.
Is there villin?
Villin is a cytoskeletal protein of microvilli of epithelial cell brush borders found principally in absorptive cells of the intestine and proximal renal tubule. Abnormal expression of villin by a significant proportion of colonic tumors suggests that it may have a role as a marker of colorectal neoplasia.
What are the main protein domains in Villin?
Villin contains two F-actin domains one in the villin core and the second in the headpiece.
What is the function of villin?
Function. Villin is believed to function in the bundling, nucleation, capping and severing of actin filaments. In vertebrates, the villin proteins help to support the microfilaments of the microvilli of the brush border.
Who is the biggest villain in the world?
Villains
| Rank | Villain | Film |
|---|---|---|
| 1 | Dr. Hannibal Lecter | The Silence of the Lambs (2) |
| 2 | Norman Bates | Psycho |
| 3 | Darth Vader | The Empire Strikes Back |
| 4 | The Wicked Witch of the West | The Wizard of Oz |
What is the work of gelsolin?
Gelsolin is a cytoplasmic, calcium-regulated, actin-modulating protein that binds to the barbed ends of actin filaments, preventing monomer exchange (end-blocking or capping). It can promote nucleation (the assembly of monomers into filaments), as well as sever existing filaments.
What are loxP sites?
LoxP sites are directional 34 bp sequences made up of two 13 bp recognition sites separated by an 8 bp spacer region. The sequences don’t occur naturally in any known genomes other than the P1 bacteriophage, and are long enough that they are unlikely to occur by chance.
What is brush border?
The brush border is a complex and highly plastic organelle required for intestinal homeostasis and is specialized for absorption of nutrients. Thousands of tightly packed microvilli form the brush border together with the area they are located on, the so-called terminal web.
What filaments form the core of microvilli?
Each microvillus has a dense bundle of cross-linked actin filaments, which serves as its structural core. 20 to 30 tightly bundled actin filaments are cross-linked by bundling proteins fimbrin (or plastin-1), villin and espin to form the core of the microvilli.
How does villin promoter mediated transgenic expression work?
Villin promoter-mediated transgenic expression of transient receptor potential cation channel, subfamily V, member 6 (TRPV6) increases intestinal calcium absorption in wild-type and vitamin D receptor knockout mice.
What are the roles of villin and Pro-ex-C?
Villin, Pro-Ex-C and progesterone/estrogen receptor expression have diagnostic and predictive roles in endocervical and endometrioid adenocarcinoma. Induction of cell stress alters the actin cytoskeleton in intestinal epithelial cells via changes in the actin-binding proteins villin-1 and gelsolin.
What does the gene VIL1 Villin 1 do?
VIL1 villin 1 [ (human)] Gene ID: 7429, updated on 6-Dec-2016. This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments.
Where is the dimerization site of villin located?
Villin has the ability to dimerize and the dimerization site is located at the amino end of the protein. Villin is an actin binding protein expressed mainly in the brush border of the epithelium in vertebrates but sometimes it is ubiquitously expressed in protists and plants.