What is the systemic inflammatory response syndrome?
Listen to pronunciation. (sis-TEH-mik in-FLA-muh-TOR-ee reh-SPONTS SIN-drome) A serious condition in which there is inflammation throughout the whole body. It may be caused by a severe bacterial infection (sepsis), trauma, or pancreatitis.
What is the difference between SIRS and sepsis?
Sepsis is a systemic response to infection. It is identical to SIRS, except that it must result specifically from infection rather than from any of the noninfectious insults that may also cause SIRS (see the image below).
Can you have SIRS without sepsis?
Sepsis is SIRS PLUS a source of infection. All sepsis meets SIRS criteria, but not the converse. SIRS criteria may be met by other etiologies such as dehydration, trauma or ischemia.
How do you treat systemic inflammatory response syndrome?
TREATMENT. Patients with SIRS or sepsis require immediate stabilization and treatment. It is recommended that treatment be centered on fluid resuscitation, antimicrobial therapy, infectious source control, and overall supportive care (e.g., pain control, nutrition).
How is systemic inflammatory response syndrome treated?
What is the initial treatment for SIRS?
Patients with SIRS or sepsis require immediate stabilization and treatment. It is recommended that treatment be centered on fluid resuscitation, antimicrobial therapy, infectious source control, and overall supportive care (e.g., pain control, nutrition).
What antibiotics treat SIRS?
Three FDA-approved antibiotics, oritavancin (Orbactiv), dalbavancin (Dalvance), and tedizolid (Sivextro), can be used for the treatment of acute bacterial skin and skin structure infections.
How does the systemic inflammatory response syndrome ( SIRS ) work?
Fung YL, Fraser JF, Wood P, Minchinton RM, Silliman CC. The systemic inflammatory response syndrome induces functional changes and relative hyporesponsiveness in neutrophils. J Crit Care. 2008 Dec. 23 (4):542-9.
How is sepsis related to systemic inflammatory response syndrome?
Thus, SIRS is not always related to infection. Although sepsis has diverged from SIRS criteria for diagnosis and management in recent years, focusing more on infectious etiologies, the pathophysiologic processes present in sepsis and noninfectious SIRS are remarkably similar, making a discussion of SIRS in critical illness appropriate.
What are the differential diagnoses of systemic inflammatory response syndrome?
Conditions to consider in the differential diagnosis of systemic inflammatory response syndrome (SIRS) include the following: Abdominal abscess. Diverticulitis. Electrical injuries. Erythema multiforme (Stevens-Johnson syndrome) Gas gangrene. Posttransplantation infections. Infective endocarditis.
How is SIRS related to multiple organ dysfunction syndrome?
Bone also endorsed a multi-hit theory behind the progression of SIRS to organ dysfunction and possibly multiple organ dysfunction syndrome (MODS). In this theory, the event that initiates the SIRS cascade primes the pump. With each additional event, an altered or exaggerated response occurs, leading to progressive illness.