What is the matrix of cartilage?
The matrix of cartilage is made up of glycosaminoglycans, proteoglycans, collagen fibers and, sometimes, elastin. Because of its rigidity, cartilage often serves the purpose of holding tubes open in the body.
What is the function of the matrix in cartilage?
The mineralized cartilage matrix serves as a scaffold for the deposition of bone, following vascular invasion, and is subsequently removed (resorbed) by large cells, chondroclasts, which are morphologically similar to the bone-resorbing cells, the osteoclasts.
What are the 3 cartilage matrix?
There are three types of cartilage: hyaline, fibrous, and elastic cartilage. Hyaline cartilage is the most widespread type and resembles glass. In the embryo, bone begins as hyaline cartilage and later ossifies. Fibrous cartilage has many collagen fibers and is found in the intervertebral discs and pubic symphysis.
What do Chondroblasts look like?
Chondroblasts are called chondrocytes when they embed themselves in the cartilage matrix, consisting of proteoglycan and collagen fibers, until they lie in the matrix lacunae….
| Chondroblast | |
|---|---|
| Diagram of chondroblasts | |
| Details | |
| Identifiers | |
| Latin | chondroblastus |
Where is the location of cartilage?
Cartilage is a connective tissue found in many areas of the body including: Joints between bones e.g. the elbows, knees and ankles. Ends of the ribs. Between the vertebrae in the spine.
How is cartilage matrix formed?
2.1. Cartilaginous anlagen are formed through condensation of mesenchymal cells that differentiate into chondrocytes and secrete cartilage extracellular matrix components (Hall and Miyake, 2000).
What is lacunae in cartilage?
In growing cartilage, the chondrocytes can divide, and the daughter cells remain close together in groups, forming a ‘nest’ of 2-4 cells. The matrix enclosed compartments that they sit in are called lacunae. (lacunae = little lakes/small pits).
What kind of collagen is found in cartilage matrix?
type II collagen
The cartilage matrix is composed of collagens (primarily type II collagen with minor collagen types IX and XI) and proteoglycans. Although a number of proteinases have been found in the arthritic joints (Nagase and Woessner, 1993), matrixins are considered to be key enzymes for the degradation of cartilage matrix.
Where are chondrocytes located?
Cartilage cells
Cartilage cells, called chondrocytes, occur at scattered sites through the cartilage and receive nutrition by diffusion through the gel; cartilage contains no blood vessels or nerves, unlike bone.
Can chondrocytes turn into chondroblasts?
In existing cartilage, chondrocytes can be damaged or destroyed. When this happens the remaining chondrocytes differentiate into chondroblasts in order to secrete more extracellular matrix and regenerate the lost cartilage tissue.
What gives rise to chondroblast?
The outer layer of the perichondrium is fibrous while the inner layer is chondrogenic, which gives rise to chondroblast cells.
Where is cartilage not found?
Cartilage is a connective tissue which provides support and flexibility to various parts of our body. Cartilage is found in the nose, ear, larynx but not in the kidney.