What is the action of histamine 2 blockers?
Histamine H2 blockers inhibit the action of histamine on gastric H2 receptors thereby decreasing gastric acidity. They were considered a breakthrough in the treatment of peptic ulcer disease when first introduced.
What is the function of H2 receptors?
The histamine receptor H2 belongs to the rhodopsin-like family of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation.
What are the mechanisms of action of H2 receptor blockers and proton pump inhibitors?
Both medications work by blocking and decreasing the production of stomach acid, but PPIs are considered stronger and faster in reducing stomach acids. However, H2 receptor blockers specifically decrease the acid released in the evening, which is a common contributor to peptic ulcers.
What drugs are H2 receptor antagonist?
Types of H2 Blockers
- Famotidine (Pepcid AC, Pepcid Oral)
- Cimetidine (Tagamet, Tagamet HB)
- Ranitidine (Zantac, Zantac 75, Zantac Efferdose, Zantac injection, and Zantac Syrup)
- Nizatidine Capsules (Axid AR, Axid Capsules, Nizatidine Capsules)
What does an H2 antagonist do?
H2 blockers are medicines that work by reducing the amount of stomach acid secreted by glands in the lining of your stomach.
What is H2 blocker medicine?
H2 blockers are a group of medicines that reduce the amount of acid produced by the cells in the lining of the stomach. They are also called ‘histamine H2-receptor antagonists’ but are commonly called H2 blockers. They include cimetidine, famotidine, nizatidine and ranitidine, and have various different brand names.
What is the best H2 receptor blocker?
Famotidine is the most potent, selective H2-receptor antagonist yet available for ulcer therapy. On a weight basis, famotidine is approximately eight times more potent than ranitidine and 40 times more potent than cimetidine.
Do H2 blockers block pepsin?
H2 blockers block a substance in the body that encourages acid production in the stomach. They work more slowly than antacids and are intended to last for longer periods of time. On the down side, they stop production of pepsin, a digestive enzyme necessary for breaking down protein.
How does H2 antagonist work?
What H2 blockers do is stop the acid-making cells in the stomach lining from responding to histamine. This reduces the amount of acid produced by your stomach. By decreasing the amount of acid, H2 blockers can help to reduce acid reflux-related symptoms such as heartburn.
What is H2-receptor antagonist used for?
H2 blockers are used to: Relieve symptoms of acid reflux, or gastroesophageal reflux disease (GERD). This is a condition where food or liquid moves up from the stomach into the esophagus (the tube from the mouth to the stomach). Treat a peptic or stomach ulcer.