What is somal translocation?
Definition: The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate.
What are immature neurons?
An immature neuron consists of a cell body (soma) containing a nucleus and cytoplasm. Axons and dendrites will grow from each immature neuron in response to chemical signals from surrounding cells. Some axons may be quite short (within the CNS) but others may extend to other parts of the body (within the PNS)
What is neuronal aggregation?
An imbalance of neuronal proteostasis, associated with protein misfolding and aggregation, leads to proteinopathies or neurodegeneration. While genetic variations and protein modifications contribute to aggregate formation, components of the proteostasis network dictate the fate of protein aggregates.
Do immature neurons proliferate?
Immature neurons from CNS stem cells proliferate in response to platelet-derived growth factor. J Neurosci. 2001 May 15;21(10):3483-91.
What are aggregates of nerve cells?
Aggregates of the protein alpha-synuclein in the nerve cells of the brain play a key role in Parkinson’s and other neurodegenerative diseases. These protein clumps can travel from nerve cell to nerve cell, causing the disease to progress.
What are clusters of neuron cell bodies?
Clusters of Neuronal Cell Bodies. Clusters of cell bodies in the central nervous system are called nuclei, while the cell bodies lining the nerves in the peripheral nervous system are called ganglia.
What do radial cells do?
Radial glia are specialized cells in the developing nervous system of all vertebrates, and are characterized by long radial processes. These processes facilitate the best known function of radial glia: guiding the radial migration of newborn neurons from the ventricular zone to the mantle regions.
Where are Tanycytes located?
The cell bodies of tanycytes, which are connected by tight junctions, are located in the ependymal layer of the 3rd ventricle and contact the cerebrospinal fluid7.
Where is NeuN expressed?
When and where is NeuN expressed NeuN is predominantly found in the nucleus of post-mitotic neurons; it first appears at embryonic day 9.5 in the mouse neural tube and corresponds with neuronal cells exiting the cell cycle1.