What is rabies glycoprotein?
The purified rabies virus glycoprotein (G) is only structural protein of the virus that induces the formation of virus-neutralizing antibodies and which confers immunity to animals. The total protective activity of the virus was recovered in the purified G protein preparation.
What proteins are in rabies?
The rabies genome encodes five proteins: nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G) and polymerase (L). All rhabdoviruses have two major structural components: a helical ribonucleoprotein core (RNP) and a surrounding envelope.
What is virus glycoprotein?
Viral glycoproteins are integral parts of enveloped viruses and they actively take part in their pathogenesis. Exploting glycoproteins, viruses enter into their host and combat with host immune system. Recent advances in technology deciphers different role of glycoproteins which are dependent on their structures.
What is the scientific name for rabies virus?
Lyssavirus: Rabies virus
Rabies virus/Scientific names
What is the rabies glycoprotein expressed in tomato an example of?
Tomato plants have been engineered to express a gene for the glycoprotein, which coats the outer surface of the rabies virus. The recombinant constructs the G-protein gene from the ERA strain of rabies virus.
Where is rabies virus from?
Worldwide, about 99% of human rabies cases come from domestic dogs. Other sources of rabies in humans include bats, monkeys, raccoons, foxes, skunks, cattle, wolves, coyotes, cats, and mongooses (normally either the small Asian mongoose or the yellow mongoose).
What is the rabies virus made of?
The rabies virus is a negative-sense, non-segmented, single-stranded RNA virus measuring approximately 60 nm × 180 nm. It is composed of an internal protein core or nucleocapsid, containing the nucleic acid, and an outer envelope, a lipid-containing bilayer covered with transmembrane glycoprotein spikes (Fig. 61-2).
How many types of rabies viruses are known?
There are two classic forms of rabies: encephalitic and paralytic. A third, much less common form is discussed later. Each of these forms evolve through five general stages: incubation, prodromal, acute neurological, coma, and death.
What is glycoprotein and glycolipid?
Glycolipid refers to lipids with a carbohydrate attached by a glycosidic (covalent) bond while glycoprotein refers to any of a class of proteins which have carbohydrate groups attached to the polypeptide chain. Thus, this is the main difference between glycolipids and glycoproteins.
Do viruses have ribosomes?
Viruses also do not possess the necessary machinery for translation, as mentioned above. They do not possess ribosomes and cannot independently form proteins from molecules of messenger RNA. Because of these limitations, viruses can replicate only within a living host cell.
What is the causative agent of rabies?
The causative agent of rabies is rabies virus (RV), a negative-stranded RNA virus of the rhabdovirus family. Neuroinvasiveness and neurotropism are the main features that define the pathogenesis of rabies.
What type of virus causes rabies?
Rabies is caused by a lyssavirus (a form of virus that causes encephalitis) that affects the saliva and nervous system. Most cases of rabies in humans are caused by a bite or scratch from an infected animal.