What is midodrine hydrochloride used for?
Midodrine is used to treat orthostatic hypotension (sudden fall in blood pressure that occurs when a person assumes a standing position). Midodrine is in a class of medications called alpha-adrenergic agonists. It works by causing blood vessels to tighten, which increases blood pressure.
What kind of drug is midodrine?
Midodrine is used in people whose daily activities are severely affected by this condition, even after other treatments are used (e.g., support stockings). It is known as a sympathomimetic (alpha receptor agonist) that acts on the blood vessels to raise blood pressure.
Does midodrine give you energy?
Midodrine increased standing systolic blood pressure by about 20 mmHg and standing diastolic blood pressure by about 15 mmHg assessed one hour after administration. Significant improvement in symptoms (syncope, increase in energy level, and depression) were reported with midodrine.
Is midodrine available in the US?
Midodrine is a vasopressor/antihypotensive agent (it raises the blood pressure). Midodrine was approved in the United States by the Food and Drug Administration (FDA) in 1996 for the treatment of dysautonomia and orthostatic hypotension.
Is midodrine still available?
Impax discontinued midodrine tablets in July 2018. Mylan has midodrine 5 mg tablets available. Sandoz discontinued midodrine tablets in mid-2018.
How long does it take midodrine to kick in?
It reaches peak concentration in the blood about an hour after swallowing a tablet, but the eff ect is brief, with levels falling to half about two to three hours later. The brain has a protective mechanism that stops some drugs from entering and very little midodrine crosses this blood-brain barrier.
Can midodrine make you pass out?
Symptoms of midodrine that could interfere with your daily life include severe dizziness, light-headedness when you’re standing, and the sensation that you’re going to pass out—also known as syncope.
How much does midodrine increase BP?
Standing systolic blood pressure is elevated by approximately 15 to 30 mmHg at 1 hour after a 10-mg dose of Midodrine, with some effect persisting for 2 to 3 hours.