What is MCM helicase?
The MCM (minichromosome maintenance) complex is a helicase which is essential for DNA replication. Recent results suggest that the MCM helicase is important for replication fork integrity, and may function as a target of the replication checkpoint.
What is the role of DNA helicase in?
DNA helicases are essential during DNA replication because they separate double-stranded DNA into single strands allowing each strand to be copied. During DNA replication, DNA helicases unwind DNA at positions called origins where synthesis will be initiated.
Does DNA helicase need transcription?
DNA helicases play an essential role in DNA replication, recombination, and repair, while RNA helicases are required in the processes of transcription, translation, RNA splicing, and assembling/disassembling RNA-protein complexes—such as ribosome.
What is the function of CDC6 during S phase?
Cdc6 is also required during S phase to allow Chk1 activation in response to replication fork inhibition, though ORC-dependent chromatin binding is not required for this function.
What genetic disease is associated with Geminin?
GMNN (Geminin DNA Replication Inhibitor) is a Protein Coding gene. Diseases associated with GMNN include Meier-Gorlin Syndrome 6 and Meier-Gorlin Syndrome 1. Among its related pathways are Cell Cycle, Mitotic and CDK-mediated phosphorylation and removal of Cdc6.
What is the function of the minichromosome maintenance complex?
The minichromosome maintenance protein complex (MCM) is a DNA helicase essential for genomic DNA replication.
How is the function of the MCM helicase regulated?
Both the loading and activation of MCM helicase are strictly regulated and are coupled to cell growth cycles. Deregulation of MCM function has been linked to genomic instability and a variety of carcinomas. Homology shared by members of the Mcm2-7 protein family.
Which is heterohexamer of the minichromosome maintenance protein?
Eukaryotic minichromosome maintenance (MCM) helicases on the other hand assemble into a heterohexamer of Mcm2–7 proteins with a unique arrangement of the six subunits. The three-dimensional structure of ring helicases from various organisms has been characterized extensively by electron microscopy and image analysis.
How does the helicase work in the pump model?
In the “steric” model, the helicase tightly translocates along one strand of DNA while physically displacing the complementary strand. In the “pump” model, pairs of hexameric helicases unwind duplex DNA by either twisting it apart or extruding it through channels in the complex.