What is disintegration in tablets?
MECHANISM OF TABLET DISINTEGRATION. Disintegration refers to the mechanical break up of a compressed tablet into small granules upon ingestion and therefore it is characterised by the breakdown of the interparticulate bonds, which were forged during the compaction of the tablet.
What are the factors affecting friability of the tablet?
A weak tablet could be due to a number of factors, including poor tablet design, low moisture content, insufficient binder and over-lubrication.
What is disintegration process?
Disintegration is defined as that state in which no residue of the unit under test remains on the screen of the apparatus or, if a residue remains, it consists of fragments of disintegrated parts of tablets component parts such as insoluble coating of the tablets or of capsule shells, or of any melted fatty substance …
What affects disintegration time?
Binders, lubricants, and hardness were found to differ in their effects on disintegration, and these factors are discussed. One two-factor interaction was found and shown to be due to a greater effect of hardness on tablets made with gelatin binder.
What is disintegration test Slideshare?
Disintegration test (U.S.P.) : For a drug to be readily available to the body , it must be in solution. For most tablets, the first important step toward solution is break down of the tablet into smaller particles or granules, a process called disintegration.
What is disintegration test apparatus?
Disintegration testers are used to test how a drug in pellet form will disintegrate in solution. Like dissolution testers, they permit researchers and medical practitioners to analyze the in vitro breakdown of powdered compounds for quality control purposes.
What affects friability?
Other mechanical properties such as friability can be influenced by the amount and type of binder used [168, 169] , the amount and type of lubricant used and the compression force applied [169,170].
What does complete disintegration meaning?
: the act or process of disintegrating or the state of being disintegrated: such as. a : the breaking down of something into small particles or into its constituent elements Some glaciers have been destabilized by warmer ocean waters.
What is the meaning of disintegration in physics?
Physics. to decay. (of a nucleus) to change into one or more different nuclei after being bombarded by high-energy particles, as alpha particles or gamma rays.
What is disintegration time?
Disintegration time is the time required for a dosage form to break up in to granules of specified size (or smaller) under carefully specified conditions. In other words DT (disintegration time) is measuring the break down of a dosage form and dissolution is measuring the drug being solubilized in the media.
Why is disintegration test important?
Overview. The disintegration test is used to show how quickly the tablet breaks down into smaller particles, allowing for a greater surface area and availability of the drug when taken by a patient.
What is the purpose of disintegration test?
What do you need to know about the disintegration test?
The disintegration test basically consists of placing a DF in an immersion medium under defined experimental conditions and measuring the time taken for the DF to disintegrate (8). The time in which the tablet or capsule should disintegrate is defined in the applicable monograph.
How does tablet disintegration relate to granule size?
In contrast, dissolution showed poor correlation with granule size (mean granule diameter) ( Fig. 7). Also, tablet disintegration did not correlate with granulation parameters or tablet dissolution rate. This indicated that granule disintegration (rather than tablet disintegration) is the rate controlling step for dissolution.
Why is disintegration testing important in pharmaceutical development?
Disintegration is a physical process related to the mechanical breakdown of a tablet or granulate particle into smaller particles. This review investigates disintegration mechanisms, pharmacopeial use of the disintegration test and scientific studies showing its utility and potential as a pharmaceutical performance test. With a proper dosage form
How is the loss of tablet friability measured?
After 4 minutes of this treatment or 100 revolutions the tablets are weighed and the weight compared with initial weight. The loss due to abrasion is a measure of tablet friability. The value is expressed in percentage.