What is CYFRA 21 1 test for?
Conclusions: Cyfra 21-1 is a sensitive and specific tumor marker of NSCLC, especially of squamous cell subtype. It also reflects the extent of the disease and has an independent prognostic role along with performance status and disease stage in NSCLC.
What are tumor marker tests?
A test that measures the amount of substances called tumor markers in tissue, blood, urine, or other body fluids. Most tumor markers are made by both normal cells and cancer cells, but they are made in higher amounts by cancer cells.
What is NSE marker?
Tumor marker, NSE: Neuron-specific enolase (NSE) is a substance that has been detected in patients with certain tumors, namely: neuroblastoma, small cell lung cancer, medullary thyroid cancer, carcinoid tumors, endocrine tumors of the pancreas, and melanoma.
What is CEA report?
A carcinoembryonic antigen (CEA) test is a blood test used to help diagnose and manage certain types of cancers. The CEA test is used especially for cancers of the large intestine and rectum. It may also mean that the cancer has spread to other parts of your body.
What is a high NSE level?
NSE levels in NSE-secreting neoplasms correlate with tumor mass and tumor metabolic activity. High levels have therefore some negative prognostic value. Falling or rising levels are often correlated with tumor shrinkage or recurrence, respectively.
What is a normal NSE level?
Twenty eight healthy adults had NSE serum level ranging from 2.58 to 17.41 ng/ml (mean level 8.01 +/- 4.40 ng /ml). The upper limit of the normal interval for serum NSE 16.6 ng/ml is defined as the mean value for healthy con- trols plus 1.96 standard deviations.
What is normal chromogranin A level?
There is a normal level of Chromogranin A in the blood, and the range currently is less than 39ng/l.. Abnormal levels can vary form forty to the thousands. The sensitivity of the test for CgA is about 80%, this means that 80% of the time abnormal levels are correctly associated with disease.
How is Cyfra 21-1 used in lung cancer screening?
Population-based screening of stage 0–I lung cancer is crucial to save lives. In this article, we describe the development of a method for the detection of a CYFRA 21-1-autoantibody complex and CYFRA 21-1 in plasma samples. The CIC/CYFRA 21-1 ratio allows the detection of stage I–IV lung cancer with 76.0% sensitivity and 87.5% specificity.
What is the role of Cyfra 21-1 in NSCLC?
The independent prognostic role of Cyfra 21-1 level may be useful in stratifying populations with advanced NSCLC or early-stage resected NSCLC as elevated Cyfra 21-1 level … Cyfra 21-1 as a biologic marker of non-small cell lung cancer.
When to use CIC / Cyfra 21-1 ratio?
Therefore, the CIC/CYFRA 21-1 ratio can be applied for the identification of asymptomatic patients in a seemingly healthy population. The anti-human-IgG (anti-human-IgG) and CYFRA 21-1 detection antibody (CYFRA 21-1-dAb) were labelled with fluorescence beads (FB) to produce anti-human-IgG-FB and CYFRA 21-1-dAb-FB, respectively.