What is a single arm study?
The simplest trial design is a single-arm trial. In this design, a sample of individuals with the targeted medical condition is given the experimental therapy and then followed over time to observe their response.
What is an arm study?
An armof a clinical trial is a group of patients receiving a specific treatment (or no treatment). Trials involving several arms, or randomized trials, treat randomly-selected groups of patients with different therapies in order to compare their medical outcomes.
What is a 2 arm parallel study?
A two-arm parallel design compares two treatments: One treatment group “A” is given one treatment and a second treatment group “B” is given a different treatment. While two-arm designs are common, multiple arms can effectively and quickly compare multiple treatments (like different doses of medication).
What is a single arm open label study?
An open-label trial, or open trial, is a type of clinical trial in which information is not withheld from trial participants. In particular, both the researchers and participants know which treatment is being administered. An open-label trial may still be randomized.
What is a single center study?
Single-center trial: a trial conducted according to a single protocol and at a single site. Multicenter trial: a trial conducted according to a single protocol but at different locations, and conducted by various researchers.
What level of evidence is a single arm study?
| Level | Interventiona | Aetiologyc |
|---|---|---|
| III-3 | A comparative study without concurrent controls: Historical control study Two or more single arm Studyj Interrupted time series without a parallel control group | A case-control study |
| IV | Case series with either post-test or pre-test/post-test outcomes | A cross-sectional study or case series |
What is the purpose of a single blind study?
A type of clinical trial in which only the researcher doing the study knows which treatment or intervention the participant is receiving until the trial is over. A single-blind study makes results of the study less likely to be biased.
Why is a multicenter study good?
Benefits. The benefits of multicenter trials include a larger number of participants, different geographic locations, the possibility of inclusion of a wider range of population groups, and the ability to compare results among centers, all of which increase the generalizability of the study.
Why is a single Centre Study bad?
Single-center studies frequently either lack the scientific rigor or external validity required to support widespread changes in practice, and their premature incorporation into guidelines may make the conduct of definitive studies more difficult.
What is a single descriptive study?
• Single descriptive or qualitative study. Qualitative research: method that systematically examines a phenomenon using an inductive approach & exploration of meaning of phenomenon; purpose is to understand & describe human experience, explore meanings & patterns; data are often narrative.