What is a necrotic core?
We defined necrotic. cores as areas in which the extracellular matrix was lacking (total. loss of collagen by picrosirius red staining) and replaced by dead. cells and cellular debris (no or fragmented nuclei by hematoxylin and. eosin staining).
What is a Fibroatheroma?
Fibroatheroma. The fibrous cap atheroma is the first of the advanced lesions of coronary atherosclerosis by the AHA classification scheme. Its defining feature is the presence of a lipid-rich necrotic core encapsulated by collagen rich fibrous tissue.
What is ruptured plaque?
Plaque rupture is defined as “an area of fibrous cap disruption whereby the overlying thrombus is in continuity with the lipid core”. 3. Intraplaque hemorrhage is defined as the deposition of blood products inside the plaque and is not necessarily associated with atherosclerotic plaque rupture.
What is the difference between plaque and thrombus?
Plaque erosion is identified when serial sectioning through a thrombus fails to show communication with a necrotic core or deep intima; the endothelium is absent, and the thrombus is superimposed on a plaque substrate primarily composed of smooth muscle cells and proteoglycans.
What does the word necrotic mean?
Definition of necrotic : affected with, characterized by, or producing death of a usually localized area of living tissue : marked by necrosis Necrotic lesions of the cornea may lead to permanent blindness or impaired vision.— Tim Beardsley …
What is the necrotic core of a plaque?
A necrotic core characterizes plaque rupture with an overlying thin-ruptured cap infiltrated by macrophages (Fig. 1). Smooth muscle cells within the cap are absent or few. The thickness of the fibrous cap near the rupture site measures 23 ± 19 μm, with 95% of the caps measuring <65 μm (1).
What is hemorrhagic plaque?
Intraplaque hemorrhage is a common feature of atherosclerotic plaques and is considered one of the identifying features of complex lesions preceding acute ischemic events. The cause of intraplaque hemorrhage is most often secondary to rupture of neovessels, which have invaded the plaque.
How does atherosclerosis cause necrosis?
Various stimuli in the plaque including high levels of oxidative stress, depletion of cellular ATP, impaired clearance of apoptotic cells and increased intracellular calcium may cause necrotic death.
What is embolus and thrombus?
A thrombus is a blood clot that forms in a vein. An embolus is anything that moves through the blood vessels until it reaches a vessel that is too small to let it pass. When this happens, the blood flow is stopped by the embolus. An embolus is often a small piece of a blood clot that breaks off (thromboembolus).
What causes a thrombus?
There are three categories of causes of thrombosis: damage to the blood vessel (catheter or surgery), slowed blood flow (immobility), and/or thrombophilia (if the blood itself is more likely to clot). Causes of thrombosis depend on whether your child has inherited or acquired thrombosis.
What is necrosis in pathology?
Necrosis is a type of cell death. It is an uncontrolled type of cell death that happens before the end of the natural life span of the cell. Pathologists use the word necrotic to describe a large area of tissue that has died of necrosis. Another common type of cell death is called apoptosis.