What is a good CTX score?
Information on the serum CTX Test
| CTX Value | Risk for ONJ |
|---|---|
| 300 to600 pg/ml (normal) | none |
| 150 to 299 pg/ml | none to minimal |
| 101 to 149 pg/ml | moderate |
| Less than 100 pg/ml | high |
What does a high N telopeptide serum mean?
increased bone resorption
Elevated levels of N-terminal telopeptide (NTx) indicate increased bone resorption. Most patients with osteopenia or osteoporosis have low, but unbalanced, bone turnover, with bone resorption dominating over bone formation.
What is CTX serum?
Serum cross-linked C-telopeptide of type I collagen (CTX) is a marker of osteoclast activity and is used to assess the level of bone resorption.
What is low bone turnover?
Low turnover disease or adynamic bone disease (ABD) is characterized by a low number of osteoblasts with normal or reduced numbers of osteoclasts. Mineralization proceeds at a normal rate, resulting in normal or decreased osteoid thickness.
What is a normal N-telopeptide?
The reference ranges for NTX in urine, as measured in nm BCE/mm creatinine, are as follows : Male: 21-83. Female (premenopausal): 17-94. Female (postmenopausal): 26-124.
What is telopeptide in blood test?
This test is used to assess the loss of bone mass (bone resorption) in cases of osteoporosis or other bone diseases such as Paget’s disease.
Is low CTX good?
Actual normal values are usually well over 300 pg/mL and are most commonly 400 pg/mL to 550 pg/mL in patients not taking bisphosphonates. Lower values represent varying degrees of suppression of normal bone turnover, sometimes also called bone remodeling or bone renewal.”
What is a good C telopeptide number?
The reference ranges for C-terminal telopeptide in serum are as follows : Female (premenopausal): 40-465 pg/mL. Female (postmenopausal): 104-1008 pg/mL. Male: 60-700 pg/mL.
What is normal C telopeptide CTX?
Reference Range(s)
| Adult Male | |
|---|---|
| 18-29 Years | 87-1200 pg/mL |
| 40-49 Years | 60-700 pg/mL |
| 50-68 Years | 87-345 pg/mL |
| Adult Female |
Can a C telopeptide blood test be definitive?
Although the C-Telopeptide blood test can provide indicators that there is something going on that could be problematic, the test results are not considered to be definitive. The number of bone markers that are in the blood can change several times throughout the day.
Is there a C terminal telopeptide for bone resorption?
The cross-linked C-terminal telopeptide of type I collagen, or CTX-I, is a sensitive but also rather variable marker of bone resorption, and several assays for the cross-linked telopeptide are commercially available.
How is the C-terminal telopeptide of Type 1 collagen measured?
Measurement of C-terminal telopeptide of type I collagen (CTX) in serum Serum CTX assays measure a fragment of the C-terminal telopeptide of type 1 collagen released during resorption of mature bone. Assay reagents are available in manual and automated formats and give good analytical performance.
Which is the most stable serum CTX or sctx?
CTX is most stable in EDTA plasma, although serum samples processed promptly would be satisfactory. sCTX shows a profound circadian rhythm, especially in non-fasting subjects; specimens should be collected from fasting patients at a well-defined time of day to minimise biological variation.