What interleukin activates osteoclasts?
Interleukin-7
Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines.
What does osteoclast activating factor do?
Osteoclast activating factor (OAF) is a lymphokine which may participate in the pathologic destruction of bone observed in a number of disorders. Stimulation of bone resorption was observed in bones treated with the same doses of OAF.
What influences osteoclast activity?
Osteoblasts can affect osteoclast formation, differentiation or apoptosis through several pathways, such as OPG/RANKL/RANK, LGR4/RANKL/RANK, Ephrin2/ephB4 and Fas/FasL pathways. In addition, cytokine released from the resorbed bone matrix, such as TGF-β and IGF-1 also affects the activity of osteoblasts.
What is osteoclast differentiation?
Osteoclasts are giant multinucleated cells that differentiate from hematopoietic cells in the bone marrow and carry out important physiological functions in the regulation of skeletal homeostasis as well as hematopoiesis.
What chemical does an osteoblast release that deactivates an osteoclast?
Calcitonin, a hormone of thyroid gland, suppresses the osteoclastic activity. The osteoclasts do not have receptors for parathyroid hormone (PTH). However, PTH stimulates the osteoblasts to secrete the cytokine called osteoclast-stimulating factor, which is a potent stimulator of the osteoclastic activity.
Which of the following stimulates osteoclast cells?
Parathyroid hormone stimulates osteoclast activity, meaning the answer is d). Osteoclasts are a type of bone cell, and they break down bone tissue to…
How is osteoclast formed?
Osteoclasts are formed by the fusion of many cells derived from circulating monocytes in the blood. These in turn are derived from the bone marrow. Osteoclasts may have as many as 200 nuclei, although most have only 5 to 20.