What does a positive double stranded DNA test mean?
Interpretation. A positive result for double-stranded DNA (dsDNA) IgG antibodies in the appropriate clinical context is suggestive of systemic lupus erythematosus (SLE).
Is there a genetic test for lupus?
What should I do if lupus runs in my family? Currently, no screening or genetic tests are available. We encourage family members to lead active, healthy lives.
Is dsDNA the same as ANA?
The anti-double-stranded DNA antibody (anti-dsDNA) is a specific type of ANA antibody found in about 30% of people with systemic lupus. Less than 1% of healthy individuals have this antibody, making it helpful in confirming a diagnosis of systemic lupus.
Does positive ANA mean lupus?
A positive result on an ANA test means that antinuclear antibodies were found in your blood. You may get a positive result if: You have SLE (lupus). You have a different type of autoimmune disease.
Is dsDNA specific for lupus?
The anti-dsDNA test is fairly specific for lupus; however, only 65-85% of people with lupus may be positive; that is, a negative anti-dsDNA does not rule out lupus. If a person has a positive ANA, an anti-dsDNA test may be used to distinguish lupus from other autoimmune disorders that have similar signs and symptoms.
Can a double stranded DNA test be negative for lupus?
Double-stranded DNA (ds – DNA) test values fluctuate and may become negative over time. System Lupus Erythematosus is diagnosed primary based on the presence of multiple standard criteria – only one of which is the ds-DNA. For more information, please read our full medical articles about Antinuclear Antibody Test and Systemic Lupus Erythematosus.
What are the clinical indications for double stranded DNA blood test?
Following are the clinical indications for performing the Double-Stranded DNA Antibody Blood Test: Monitoring the progress of lupus. Following up to a positive test for antinuclear antibody (ANA) Differentiating lupus from other autoimmune disorders. Fatigue. Joint pain. Fever. Rash.
What kind of blood test is associated with lupus?
A positive antinuclear antibodies (ANA) blood test is associated with lupus in 95% of cases; a positive Double Stranded DNA Antibody Blood Test is associated with lupus in 50-70% of cases.
Can a positive ANA test be used for lupus?
While a positive ANA test is seen in about 95% of lupus cases, it may be seen in many other conditions as well. The anti-dsDNA test is fairly specific for lupus; however, only 65-85% of people with lupus may be positive; that is, a negative anti-dsDNA does not rule out lupus.