What are single donor platelets used for?
Both platelet concentrates (PC) derived from whole blood or single donor platelets (SDP) obtained from a single donor by apheresis are indicated to treat acute hemorrhage secondary to thrombocytopenia or to provide prophylaxis from hemorrhage in patients with bone marrow aplasia.
What is the guideline for transfusion rates of platelets?
Consider increasing the threshold for prophylactic platelet transfusion to between 10 and 20 × 109/l in patients judged to have additional risk factors for bleeding. Individual review is required.
At what level should platelets be infused?
Most platelet products are transfused into non-bleeding thrombocytopenic patients. The transfusion “trigger” or threshold for transfusion of these patients is now generally accepted to be 10,000/μL based on the results of a number of studies.
What is single donor platelet transfusion?
It is possible to obtain only Platelets from a Donor by a process called ‘Apheresis’. Like in routine blood donation, 350 ml. of blood is drawn from the donor. This is sent to a special Blood Bag, which is housed inside the Apheresis Machine. The Platelets so collected are called Single Donor Platelets (SDP).
What is the criteria for donating platelets?
General Guidelines. To donate blood or platelets, you must be in good general health, weigh at least 110 pounds, and be at least 16 years old. Parental consent is required for blood donation by 16 year olds; 16 year olds are NOT eligible to donate platelets.
Who can donate single donor platelets?
At the age above 18 years, generally good health who meets weight and height requirements may become eligible to donate Platelets. Person who are not on aspirin products for at least 3 full calendar days prior to the donation. The eligibility requirement for Platelets donation is same as a whole blood donation.
How do you give a platelet transfusion?
A platelet transfusion is when you are given platelets from carefully screened donors. Sometimes this is called a platelet infusion. You will be given platelets by a drip into one of your veins. This increases the number of platelets in your blood.
Does platelet transfusion require blood group matching?
Platelets are often transfused regardless of their ABO group because ABO antigens are only weakly expressed on platelets. Most adults have soluble A or B antigenic substances in their blood that are capable of neutralizing the antibodies in small amounts of ABO-incompatible plasma, such as one platelet transfusion.
What platelet level requires a blood transfusion?
There is reasonable consensus that for patients who are bleeding, septic, or hemodynamically unstable, the threshold for transfusion should be raised to 15,000-20,000/µL. Patients with life-threatening bleeding in the chest or head are usually transfused at higher platelet count thresholds (30,000-50,000/µL).
Is cross matching required for platelet transfusion?
Platelet transfusions from RhD-positive donors to recipients with anti-D antibodies do not result in hemolysis, because they contain very few RBCs. Only products containing >2 mL of incompatible RBCs require a serologic crossmatch per AABB standards.
Which is better SDP or RDP?
Efficacy: One unit of platelet RDP increases platelet count by approximately 5 x 109/L (i.e. 5000/mm3). SDP is as effective as RDP. SDP is more expensive & its use should be limited to cases of platelet refractoriness & in limiting donor exposure.
How much platelets increase by SDP?
Each unit of RDP will raise the patient’s platelet count 5000–10,000/μl. The standard six‐pack of RDP will therefore raise the platelet count 30,000–60,000/μl. A single unit of SDP will raise the patient’s platelet count by the same amount (30,000–60,000/μl).
What are the clinical indications for platelet transfusion?
Clinical Indications for platelet transfusion for patients with clinically signifi- cant bleeding include: 1. Platelet transfusion is indicated for patients with clinically significant bleeding in whom thrombocytopenia is thought to be a major contributory factor, even if the platelet count is >10×109/L. 2.
Are there any contraindications for platelet transfusions?
Clinical contraindications for platelet transfusions include: 1. Platelet transfusion is not indicated in patients where bleeding is unrelated to proven or anticipated decreased platelet count or to functional platelet defects.
How many units of platelets do you need for a transfusion?
Patients on Plavix (clopidogrel) with severe bleeding 2 units of platelets may be given. A single unit of platelets is the standard for transfusion, with the exception of patients on Plavix with bleeding.
When do you need a platelet transfusion for DIC?
Platelet transfusion is not indicated for patients with chronic DIC or for whom there is no bleeding. 5. In general, platelet transfusion is not indicated in immune thrombocytopenia unless there is clinically significant bleeding. Clinical Indications for prophylactic platelet transfusion for prevention of bleeding include: