How does mifamurtide work?
It works by activating macrophages and monocytes (types of white blood cell that form part of the immune system). The precise way that mifamurtide works in osteosarcoma is not fully understood, but it is thought to cause the white blood cells to release chemicals that kill the cancerous cells.
Is mifamurtide an immunotherapy?
Other derivatives of muramyl dipeptide-nor-MDP, des-muramyl peptides and muramyl tripeptide phosphatidyl ethanolamine (L-MTP-PE or mifamurtide), are considered as immunostimulants and adjuvants in the immunotherapy of cancer and infections.
What is mifamurtide used for?
Mifamurtide (pronounced mee-fam-ure-tide) is also called by its brand name, Mepact. It is a treatment for osteosarcoma, a type of bone cancer. It is for children and young people aged between 2 and 30 years. You have it with chemotherapy after surgery to help lower the risk of the cancer coming back.
What is MAP chemotherapy?
Chemotherapy combination, named MAP, including cisplatin, doxorubicin, and high-dose methotrexate, was mainly used for the therapy of osteosarcoma,[31,33–39] while MAP +, used for the treatment of patients with metastatic disease, seemed to improve EFS.
Can you take too much leucovorin?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of leucovorin is not likely to cause life-threatening symptoms. However, leucovorin overdose can make other medications less effective.
How often do you have mifamurtide in the chest?
This is a long plastic tube that gives the drugs into a large vein, either in your chest or through a vein in your arm. It stays in while you’re having treatment, which may be for a few months. You have the treatment twice a week, at least 3 days apart. You have it for 12 weeks. Then you have it once a week for another 24 weeks.
How old do you have to be to get Mifamurtide treatment?
Mifamurtide (Mepact) Mifamurtide (pronounced mee-fam-ure-tide) is also called by its brand name, Mepact. It is a treatment for osteosarcoma, a type of bone cancer. It is for children and young people aged between 2 and 30 years. You have it with chemotherapy after surgery to help lower the risk of the cancer coming back.
How is Mifamurtide used in the treatment of cancer?
Mifamurtide is a targeted cancer drug. It boosts the immune system to kill cancer cells. It makes the immune system produce certain types of white blood cells called monocytes and macrophages. You have the treatment through a drip into your arm or hand. A nurse puts a small tube (a cannula) into one of your veins and connects the drip to it.