What is the survival rate of AL amyloidosis?
Five percent of patients with AL amyloidosis survived for 10 years or more. THE MEDIAN SURVIVAL in 474 patients with primary systemic (AL) amyloidosis was 13 months. 1 Despite the use of melphalan and prednisone, the median survival is still only 17 to 18 months.
What are the 2 types of amyloidosis?
The most common types of amyloidosis are:
- AL (Primary) Amyloidosis.
- AA (Secondary) Amyloidosis.
- Familial ATTR Amyloidosis.
- Wild-Type (Senile) ATTR Amyloidosis.
What are the stages of cardiac amyloidosis?
Stage I (TnI <0.1 ng/mL and NT-proBNP <332 pg/mL), stage II (TnI >0.1 ng/mL and NT-proBNP >332 pg/mL), and stage III (TnI >0.1 ng/mL and NT-proBNP >332 pg/mL). Stage I (TnI <0.1 ng/mL and BNP <81 pg/mL), stage II (TnI >0.1 ng/mL or NT-proBNP >81 pg/mL), and stage III (TnI >0.1 ng/mL and NT-proBNP >81 pg/mL).
Can you survive AL amyloidosis?
There is no cure for patients with AL amyloidosis but more frequently patients can go into remission with drug therapy. In our experience, the majority of patients surviving the first six months can often start recovering thereafter and can typically live normal or near normal lives for years to come.
Is amyloid an autoimmune disease?
With AA amyloidosis, the underlying condition is an autoimmune disease or chronic infection.
What triggers AL amyloidosis?
AL Amyloidosis is caused by the accumulation of an immunoglobulin light chain protein. Typically, the protein is caused by a malignant or pre-malignant growth of identical, (clonal) lymphocytes or plasma cells that continue to produce these immunoglobulin light chain proteins.
Is AL amyloidosis painful?
You may experience pain, numbness or tingling of your fingers or numbness, lack of feeling or a burning sensation in your toes or the soles of your feet. If amyloid affects the nerves that control your bowel function, you may experience periods of alternating constipation and diarrhea.