What is the structure of Sulpha drug?
The basic structure of sulfonamide cannot be modified if it is to be an effective competitive “mimic” for p-aminobenzoic acid. Essential structural features are the benzene ring with two substituents para to each other; an amino group in the fourth position; and the singly substituted 1-sulfonamido group.
What are sulfa drugs in chemistry?
sulfa drug, also called sulfonamide, any member of a group of synthetic antibiotics containing the sulfanilamide molecular structure. Sulfa drugs were the first chemical substances systematically used to treat and prevent bacterial infections in humans.
Which is functional group present in sulfonamide structure?
In chemistry, the sulfonamide functional group (also spelled sulphonamide) is -S(=O)2-NH2, a sulfonyl group connected to an amine group. A sulfonamide (compound) is a compound that contains this group. The general formula is RSO2NH2, where R is some organic group.
What is sulfonamide structure?
Structure of Sulfonamides Sulfonamides are composed of a sulfur atom that has two sets of double bonds to two oxygen atoms, a carbon-based side group, and a nitrogen atom bonded to the sulfur itself. In organic chemistry, an amide contains a carbonyl group bonded to a nitrogen atom.
What is the structure of sulfanilamide?
C6H8N2O2S
Sulfanilamide/Formula
What are sulfa drugs give example?
Examples of sulfonamides includes sulfadiazine, sulfamethizole (brand name: Thiosulfil Forte), sulfamethoxazole (Gantanol), sulfasalazine (Azulfidine), sulfisoxazole (Gantrisin), and various high-strength combinations of three sulfonamides. Sulfa drugs kill bacteria and fungi by interfering with cell metabolism.
Is sulfonamide a base or acid?
A sulfonamide contains two important functional groups in the pharmaceutically relevant pH range of 4 to 9 as shown in Figure 1: one acidic amide moiety (N1) and one basic amine moiety (N2).
Which is the derivatives of sulfonamides?
Some sulfonamides are also devoid of antibacterial activity, e.g., the anticonvulsant sultiame. The sulfonylureas and thiazide diuretics are newer drug groups based upon the antibacterial sulfonamides.
What is the difference between sulfonamide and sulfanilamide?
Pharmacokinetics. A small amount of sulfanilamide is absorbed following topical application or when administered as a vaginal cream or suppository (through the vaginal mucosa). It is metabolized by acetylation like other sulfonamides and excreted through the urine.
What is the Iupac name of sulfanilamide?
Sulfanilamide sodium | C6H7N2NaO2S – PubChem.
Which antibiotics are sulfa?
Sulfonamides, or “sulfa drugs,” are a group of medicines used to treat bacterial infections….Commonly prescribed sulfonamides include:
- Gantrisin (sulfisoxazole)
- Bactrim or Septra (trimethoprim and sulfamethoxazole)
- Sulfadiazine.
- Azulfidine (sulfasalazine)
- Zonegran (zonisamide)
Is amoxicillin a sulfa drug?
Amoxicillin belongs to a class of drugs called penicillins. It is a penicillin type antibiotic and it does not have sulfa in it.