What is the role of the mediator protein?
Mediator is a multiprotein complex that functions as a transcriptional coactivator in all eukaryotes. Mediator complexes interact with transcription factors and RNA polymerase II. The main function of mediator complexes is to transmit signals from the transcription factors to the polymerase.
What is RNA polymerase II responsible for?
Eukaryotic RNA polymerase II (pol II) is a 12-subunit DNA-dependent RNA polymerase that is responsible for transcribing nuclear genes encoding messenger RNAs and several small nuclear RNAs (1).
What is a Mediator in molecular biology?
A complex of proteins that allows initiation of cell- and/or cell cycle-specific control of eukaryotic transcription.
What is a mediator in pharmacology?
Mediators can be defined as compounds that are either locally released or carried in blood or tissue fluids and that may participate in initiating, perpetuating, or aggravating a pathological process.
How does RNA polymerase 2 work?
RNA polymerase II (Pol II) transcribes all protein-coding genes and many noncoding RNAs in eukaryotic genomes. Although Pol II is a complex, 12-subunit enzyme, it lacks the ability to initiate transcription and cannot consistently transcribe through long DNA sequences.
What is the role of the mediator?
The mediator assists and guides the parties toward their own resolution. The mediator does not decide the outcome, but helps the parties understand and focus on the important issues needed to reach a resolution.
What is a mediator in epidemiology?
Researchers may hypothesize that some or all of the total effect of exposure on an outcome operates through a mediator, which is an effect of the exposure and a cause of the outcome. When a mediator is hypothesized, the total effect can be broken into two parts: the direct and indirect effect.