What is the most common location of cholangiocarcinoma?
Perihilar cholangiocarcinoma (also known as a Klatskin tumor) begins in an area called the hilum, where the right and left major bile ducts join and leave the liver. It is the most common form of the disease, accounting for more than half of all cases.
What ducts are included in the biliary tree?
biliary tree
- common hepatic duct.
- cystic duct.
- ​common bile duct. ampulla of Vater. sphincter of Oddi.
- subvesical bile ducts.
How rare is hilar cholangiocarcinoma?
Hilar cholangiocarcinoma (HC) is a rare disease with a poor prognosis which typically presents in the 6th decade of life. Of the 3,000 cases seen annually in the United States, less than one half of these tumors are resectable.
Which parasite causes cholangiocarcinoma?
Two parasites are commonly involved. One is Opisthorchis verrini, which is found in Southeast Asian countries, including Thailand, Lao People’s Democratic Republic, Vietnam, and Cambodia. The other is Clonorchis sinensis, which is common in rural areas of Korea and China.
What is hilar cholangiocarcinoma?
Hilar cholangiocarcinoma is a type of bile duct cancer that occurs in the bile ducts that lead out of the liver (hepatic ducts) and join with the gallbladder. Hilar cholangiocarcinomas are also known as Klatskin tumors.
What does the biliary tree do?
The biliary tree (also known as the biliary tract or biliary system) is comprised of the gallbladder, liver and bile ducts. These structures produce, store, and release bile to the small intestines, where it aids in the digestion of lipids.
What is biliary tree?
The biliary tree is a system of vessels that directs these secretions from the liver, gallbladder and pancreas through a series of ducts into the duodenum. (Because of the structure of the connections to each organ, the biliary tree, or tract, bears some resemblance to a tree and its branches, hence the name.)
Is hilar cholangiocarcinoma curable?
Background. Hilar cholangiocarcinoma is the most common malignant tumor affecting the extrahepatic bile duct. Surgical treatment offers the only possibility of cure, and it requires removal of all tumoral tissues with adequate resection margins.
What causes hilar cholangiocarcinoma?
Scarring of the liver caused by a history of chronic liver disease increases the risk of cholangiocarcinoma. Bile duct problems present at birth. People born with a choledochal cyst, which causes dilated and irregular bile ducts, have an increased risk of cholangiocarcinoma. A liver parasite.
What is Stage 3 cholangiocarcinoma?
In stage IIIB, cancer has spread to organs or tissues near the liver, such as the duodenum, colon, stomach, common bile duct, abdominal wall, diaphragm, or the part of the vena cava behind the liver, or the cancer has spread to nearby lymph nodes.
Where does hilar cholangiocarcinoma occur in the body?
Hilar cholangiocarcinoma is a type of bile duct cancer that occurs in the bile ducts that lead out of the liver (hepatic ducts) and join with the gallbladder.
Which is the most common type of cholangiocarcinoma?
Cholangiocarcinoma may arise anywhere within the biliary tree but tumors involving the biliary confluence (hilar cholangiocarcinoma) are the most common.
Is there a cure for hilar cholangiocarcinoma before surgery?
Liver transplant. People with early-stage hilar cholangiocarcinoma who aren’t able to undergo surgery may consider liver transplant. Chemotherapy and radiation are typically used before the liver transplant in order to kill as many cancer cells as possible before surgery. This treatment typically involves: Intravenous chemotherapy…
What kind of cancer is in the biliary tree?
Hilar cholangiocarcinoma is a form of bile duct cancer which afflicts this part of the biliary tree. This is also termed perihilar cholangiocarcinoma or Klatskin tumour. Anatomy of the bile duct. The area shaded blue is where hilar cholangiocarcinoma arises.