What is the mechanism of action of flucytosine?
Flucytosine is a pyrimadine analogue that has activity against fungal species by interfering with purine and pyrimidine uptake and by deaminated to 5-fluorouracil (5-FU) and then converted to 5-fluorodeoxyuridylic acid monophosphate, a noncompetitive inhibitor of thymidylate synthetase which interferes with DNA …
What is flucytosine used to treat?
Flucytosine is an antifungal prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of serious infections caused by certain strains of two types of fungi: Candida and Cryptococcus.
When should Flucytosine levels be checked?
Because of the drug’s short half-life (3-6 hours), therapeutic monitoring is typically performed at peak levels, 1 to 2 hours after an oral dose or 30 minutes after an intravenous administration.
Is Flucytosine an antimetabolite?
Flucytosine (5-fluorocytosine, 5-FC) is an antifungal agent originally developed in 1957 as an antimetabolite. Although it has found no role as an anti-tumor agent, it is used for the treatment of certain fungal infections.
Why is flucytosine not used as monotherapy?
Flucytosine (5FC) is the fluorinated analogue of cytosine which was first used for the treatment of human invasive mycoses in 1968 (21). The drug has a narrow spectrum of activity and is seldom used as monotherapy due to the emergence of resistance.
When should I take Flucytosine?
Flucytosine is used to treat serious fungal infections in the body. It belongs to a class of drugs known as antifungal drugs. It is often used with other medications. It works by slowing the growth of certain types of fungus.
How do you take Flucytosine?
Take each dose with a full glass (8 ounces) of water. Flucytosine may cause nausea and vomiting. If you take more than one capsule per dose, swallow one capsule at a time over a 15-minute period to help prevent nausea and vomiting. Use this medicine for the full prescribed length of time.
What is another name for flucytosine?
Flucytosine, also known as 5-fluorocytosine (5-FC), is an antifungal medication.