What is receptor down-regulation?
Receptor downregulation is characterized by a decrease in total receptor number in the cell due to endocytosis and subsequent degradation of the receptors caused by long-term exposure to agonists (see Fig. 5-7). Downregulation is also an important cellular mechanism during long-term administration of therapeutic drugs.
What downregulation means?
Medical Definition of downregulation : the process of reducing or suppressing a response to a stimulus specifically : reduction in a cellular response to a molecule (as insulin) due to a decrease in the number of receptors on the cell surface.
What is down-regulation neurotransmitters?
when the number of receptors for a neurotransmitter are decreased, typically in response to an increase in the release of that neurotransmitter. Down-regulation can also refer more generally to the decreasing of any cellular component (e.g., protein, RNA).
What does it mean when a gene is up or down regulated?
The up-regulated genes are mainly components that control cellular proliferation, whereas the down-regulated genes consist of proteins exposed on or secreted from the cell surface.
What is down regulation quizlet?
Down-regulation. prolonged exposure to high hormone concentrations can decrease the # of receptors of that hormone; desensitizes the target cells, so they response less vigoursly to hormonal stimulation, preventing them from overreacting to persistently high hormone levels.
Why do receptors down regulate?
Downregulation of receptors can also occur when receptors have been chronically exposed to an excessive amount of a ligand, either from endogenous mediators or from exogenous drugs. This results in ligand-induced desensitization or internalization of that receptor.
What is down regulation in hormone?
Downregulation: An decrease in the number of receptors on the surface of target cells, making the cells less sensitive to a hormone or another agent.
What is receptor regulation pharmacology?
Receptor regulation is the homeostatic increase or decrease in receptor activity or number, in response to activation or blockade.
Why does down regulation occur?
The process of downregulation occurs when there are elevated levels of the hormone insulin in the blood. When insulin binds to its receptors on the surface of a cell, the hormone receptor complex undergoes endocytosis and is subsequently attacked by intracellular lysosomal enzymes.
Which of the following is an example of down regulation?
Downregulation: An decrease in the number of receptors on the surface of target cells, making the cells less sensitive to a hormone or another agent. For example, insulin receptors may be downregulated in type 2 diabetes.
Which is the correct definition of receptor down regulation?
(redirected from Receptor down-regulation) Also found in: Dictionary. Cell biology The reduction of a cell’s response to a hormone or other ligand by internalizing its cognate receptor and degrading it within a coated pit; downregulation is a mechanism by which receptors respond to an excess of ligands.
What does downregulation mean in cell biology?
Cell biology The reduction of a cell’s response to a hormone or other ligand by internalizing its cognate receptor and degrading it within a coated pit; downregulation is a mechanism by which receptors respond to an excess of ligands.
Which is receptor down regulation increases q27e or r16g?
Whereas Q27E induces complete resistance to downregulation in combination with R16, R16G increases agonist-mediated receptor down-regulation in both haplotypes (5). Medical browser? Full browser?
What causes a decrease in receptor number in the cell?
Receptor downregulation is characterized by a decrease in total receptor number in the cell due to endocytosis and subsequent degradation of the receptors caused by long-term exposure to agonists (see Fig. 5-7 ).