What is propofol injection used for?
Propofol is an intravenous (IV) sedative-hypnotic agent that can be used for initiation and maintenance of Monitored Anesthesia Care (MAC) sedation, combined sedation and regional anesthesia, induction of general anesthesia, maintenance of general anesthesia, and intensive care unit (ICU) sedation of intubated.
How many mg propofol per mL?
Each ml of emulsion for injection/ infusion contains 10 mg of propofol. Sodium 0.035 mg.
How much propofol is used for sedation?
Generally, a propofol loading dose of 40 mg to 50 mg is given with further smaller bolus loads (10 mg to 20 mg) to maintain sedation, with a typical total dose between 100 mg and 300 mg.
How much propofol is too much?
-The maximum dosage of propofol for adult sedation in an intensive care setting should not exceed 4 mg/kg/hour.
What is the main side effect of propofol?
Common propofol side effects may include: mild itching or rash; fast or slow heart rate; or. slight burning or stinging around the IV needle.
What happens if you push propofol too fast?
A rapid bolus injection can result in undesirable cardiorespiratory depression including hypotension, apnea, airway obstruction, and oxygen desaturation. For initiation of MAC sedation, either an infusion or a slow injection method may be utilized while closely monitoring cardiorespiratory function.
How quickly does propofol work?
Onset of action: Propofol has a rapid onset of action that is dose-dependent and less than a minute. Duration of action: An induction dose of propofol will have a clinical effect for approximately 10 minutes.
How long does it take propofol to wear off?
The half-life of elimination of propofol has been estimated to be between 2 and 24 hours. However, its duration of clinical effect is much shorter, because propofol is rapidly distributed into peripheral tissues. When used for IV sedation, a single dose of propofol typically wears off within minutes.
Can you get addicted to propofol?
Because propofol has intrinsic limitations, including a lack of street availability and the requirement for intravenous administration, it is generally believed not to be of interest to drug abusers. However, healthcare providers in Western society can easily become addicted to propofol because of easy access.
Is propofol a general anesthesia?
Propofol is a short-acting, lipophilic intravenous general anesthetic. The drug is unrelated to any of the currently used barbiturate, opioid, benzodiazepine, arylcyclohexylamine, or imidazole intravenous anesthetic agents.
Can propofol be reversed?
Propofol is a remarkable drug that has revolutionized sedation for patients undergoing endoscopic procedures. It can produce rapid and, when necessary, deep sedation, and its effects can be reversed within seconds to minutes. Because it has proven to be more effective than hypnotics (such as versed)…
What is the treatment for propofol overdose?
Supportive treatment. There is no specific antidote for too much propofol. But it is a short-acting medication. If the blood pressure is too low, the anesthesiologist will give fluids and meds to support bp. If breathing slows or stops, we would ventilate by mask and/or insert a breathing tube to support breathing.
What drug class is propofol?
In the US, Propofol (propofol systemic) is a member of the drug class general anesthetics and is used to treat Anesthesia.