What is lipoprotein and its classification?
Lipoproteins are classified based on their density, electrophoretic mobility, and nature of apoprotein content. Upon centrifugation, lipoproteins with high protein content sediment easily due to their high density whereas lipoproteins with high lipid content have low density and will float on the surface.
What is lipoprotein PPT?
1. LIPOPROTEINS Definition: A lipoprotein is a biochemical assembly that contains both proteins and lipids , bound to the proteins , which allow fats to move through the water inside and outside cells.
What are the 5 types of lipoproteins?
Plasma lipoproteins are separated by hydrated density; electrophretic mobility; size; and their relative content of cholesterol, triglycerides, and protein into five major classes: chylomicrons, very-low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), low-density lipoproteins (LDL), and high- …
What is lipoproteins and their functions?
A lipoprotein is a biochemical assembly whose primary function is to transport hydrophobic lipid (also known as fat) molecules in water, as in blood plasma or other extracellular fluids. Examples include plasma lipoprotein particles (HDL, LDL, IDL, VLDL and chylomicrons).
What are lipoproteins classification and their importance?
There are four major classes of circulating lipoproteins, each with its own characteristic protein and lipid composition. They are chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL).
What are types of lipoproteins?
Plasma lipoproteins can be divided into seven classes based on size, lipid composition, and apolipoproteins (chylomicrons, chylomicron remnants, VLDL, IDL, LDL, HDL, and Lp (a)). Chylomicron remnants, VLDL, IDL, LDL, and Lp (a) are all pro-atherogenic while HDL is anti-atherogenic.
What means lipoprotein?
Lipoproteins are substances made of protein and fat that carry cholesterol through your bloodstream. There are two main types of cholesterol: High-density lipoprotein (HDL), or “good” cholesterol. Low-density lipoprotein (LDL), or “bad” cholesterol.
What are the 4 types of lipoproteins?
What is the purpose of lipoproteins?
The primary function of lipoproteins is the transportation and delivery of fatty acids, triacylglycerol, and cholesterol to and from target cells in many organs.
What is the role of lipoprotein in the body?
Lipoproteins are complex aggregates of lipids and proteins that render endogenous lipids compatible with the aqueous environment of body fluids (Brown, 2007). The major physiological role of lipoproteins is to transport water-insoluble lipids from their point of origin to their respective destinations.
What is the main function of lipoproteins?
They are more complicated than glycolipids, forming large particles with several classes of lipid, and protein. The primary function of lipoproteins is the transportation and delivery of fatty acids, triacylglycerol, and cholesterol to and from target cells in many organs.
How are lipoproteins classified according to their densities?
The classification into chylomicrons (CM), very low-density (VLDL), low-density (LDL), and high-density (HDL) lipoproteins is based on their relative contents of protein and lipid that determine the densities of these lipoprotein classes.
How are lipoproteins classified by their electrophoretic mobility?
Lipoproteins are also classified by their electrophoretic mobility on agarose gels into c~, pre13, and 13 lipoproteins, corresponding to HDL, VLDL, and LDL density classes respectively; CM, when present, remain at the electrophoretic origin.
How are apolipoproteins different from other lipo proteins?
General Structure of Lipo proteins Some apolipoproteins are integral and cannot be removed, whereas others can be freely transferred to other lipoproteins. 12/22/13 Biochemistry for medics 4 5. Classification of Lipoproteins Lipoproteins can be classified in three ways1) Based on density- They are separated by Ultracentrifugation.
Why is VLDL a specific type of lipoprotein?
Metabolism of VLDL The liver and many extrahepatic tissues express the LDL (apo B100, E) receptor. It is so designated because it is specific for apo B-100 but not B-48, which lacks the carboxyl terminal domain of B-100 containing the LDL receptor ligand, and it also takes up lipoproteins rich in apo E. 12/22/13 Biochemistry for medics 28