What is HSP70 antibody?
Primary antibody notes The HSP 70 family is a set of highly conserved proteins that are induced by a variety of biological stresses, including heat stress, in every organism in which the proteins have been examined.
What is the function of HSP70?
Hsp70 proteins are central components of the cellular network of molecular chaperones and folding catalysts. They assist a large variety of protein folding processes in the cell by transient association of their substrate binding domain with short hydrophobic peptide segments within their substrate proteins.
What is heat shock protein 70 expression?
Heat shock protein 70 (Hsp70) is a molecular chaperone that is expressed in response to stress. In this role, Hsp70 binds to its protein substrates and stabilize them against denaturation or aggregation until conditions improve.
Where is HSP70 found?
The 70-kDa heat shock protein (HSP70) family constitutes one of the most conserved protein families in evolution. HSP70s are monomeric proteins that reside in any adenosine-5′-triphosphate (ATP)-containing eukaryotic intracellular compartment and can also be found in cell membranes (Gehrmann et al.
What is the molecular weight of HSP70?
Product Information
| Tested Reactivity | human, mouse, rat |
|---|---|
| Immunogen | HSP70 fusion protein Ag1446 |
| Full Name | heat shock 70kDa protein 1A |
| Calculated molecular weight | 70 kDa |
| Observed molecular weight | 66-70 kDa |
What is the difference between Hsp70 and Hsp90?
Heat shock proteins 90 (Hsp90) and 70 (Hsp70) are two families of highly conserved ATP-dependent molecular chaperones that fold and remodel proteins. In contrast, bacterial Hsp90 and Hsp70 are less complex; Hsp90 acts independently of co-chaperones, and Hsp70 uses two co-chaperones.
What are the benefits of heat shock proteins?
Heat shock proteins are the dominant antigens during infections and during the progression of certain autoimmune diseases. Heat shock proteins inhibit inflammatory pathways. Heat shock proteins make healthy cells stronger by protecting cells against stress and injuries, making you more resistant to diseases.
Is HSP90 a chaperone?
Heat shock protein 90 (HSP90) is a molecular chaperone that is conserved from bacteria to humans and facilitates the maturation of substrates (or clients) that are involved in many different cellular pathways.