What is Dotatate therapy?
Lu-DOTATATE therapy is an important treatment option in somatostatin receptor type-2-positive pancreatic, nonpancreatic gastroenteropancreatic-NETs, and lung NETs including metastatic NETs with an unknown primary site and significantly contributed to patients’ OS.
What are the side effects of PRRT treatment?
The most common side effects of PRRT are nausea, vomiting, belly pain, and temporary hair loss. Nausea is mainly caused by the amino acid infusion. You will be given anti-nausea medicine to lessen this side effect. PRRT can cause low blood counts, which tend to occur after a month or more of treatment.
Does PRRT shrink tumors?
PRRT is a treatment option that is highly effective in controlling advanced, metastatic or inoperable, progressive neuroendocrine tumors. PRRT is rarely curative but has been shown to help relieve symptoms, shrink tumor lesions, and slow the progression of the disease5.
What is the drug Lutathera used for?
The U.S. Food and Drug Administration today approved Lutathera (lutetium Lu 177 dotatate) for the treatment of a type of cancer that affects the pancreas or gastrointestinal tract called gastroenteropancreatic neuroendocrine tumors (GEP-NETs).
What is Dotatate scan?
A Ga-68 dotatate scan is a test used to check the body for the presence of neuroendocrine tumor cells. You will have this test done in the Nuclear Medicine department. Nuclear medicine is a type of radiology that uses radioactive materials to diagnose or treat diseases.
What is Lutathera?
Lutathera is a medication used to treat neuroendocrine tumors. It can help make the tumors grow more slowly or stop them from growing. It can also help manage symptoms caused by the tumors. Lutathera is a radioactive targeted therapy. It has 2 main parts: a radioactive part and a tumor-targeted part.
Is PRRT painful?
PRRT with Lu 177 is generally well tolerated. Common side-effects of Lu-177 therapy are nausea, vomiting, and abdominal pain. Other less common side-effects are bone, liver and kidney toxicity, and mild hair loss.
Is Lutathera a biologic?
Everolimus is also approved as a targeted biologic. Then we have Lutathera, which is also known as peptide receptor radionuclide therapy treatment.
Is Lutathera a radiation?
Radiation exposure: Treatment with LUTATHERA will expose you to radiation which can contribute to your long-term radiation exposure. Overall radiation exposure is associated with an increased risk for cancer. The radiation will be detectable in your urine for up to 30 days following administration of the drug.
What kind of therapy is Lu 177 dotatate?
Lu 177-Dotatate is a type of Radioisotope therapy, also called Peptide Receptor Radionuclide Therapy or PRRT. Radioisotope therapy delivers radiation directly into the cancer cells by adding radioactive material to proteins that bind with specific cancer cells.
What kind of neuroendocrine tumor does 177Lu dotatate treat?
177Lutetium-[DOTA°,Tyr3]octreotate (177Lu-DOTATATE) is a type of peptide receptor radionuclide therapy that garnered FDA approval in January 2018 for the treatment of somatostatin receptor-positive gastroenteropancreatic (GEP) neuroendocrine tumor (NET) patients.
How is 177Lu dotatate used in the treatment of GEP NETs?
177Lu-DOTATATE represents a unique addition to the treatment armamentarium for GEP NETs because of its potential to elicit tumor cytoreduction, which is rare among other existing treatment options, and prolonged disease control. Where 177Lu-DOTATATE fits into the treatment sequence for GEP NET patients remains an area of active investigation.
What are the side effects of lutetium dotatate?
Common side effects may include: 1 nausea, vomiting; 2 high blood sugar; 3 low potassium; or 4 abnormal liver function tests.