What is donepezil used to treat?
Donepezil is used to treat dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may cause changes in mood and personality) in people who have Alzheimer’s disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn.
What are the benefits of taking donepezil?
Donepezil is used to treat confusion (dementia) related to Alzheimer’s disease. It does not cure Alzheimer’s disease, but it may improve memory, awareness, and the ability to function. This medication is an enzyme blocker that works by restoring the balance of natural substances (neurotransmitters) in the brain.
What are the contraindications of donepezil?
Who should not take DONEPEZIL HCL?
- neuroleptic malignant syndrome, a reaction characterized by fever, muscle rigidity and confusion.
- atrioventricular block, a type of slow heart rhythm disorder.
- sick sinus syndrome.
- sinus bradycardia.
- asthma.
- stomach or intestinal ulcer.
- bleeding of the stomach or intestines.
What is the mode of action of donepezil?
Mechanism of Action Donepezil binds reversibly to acetylcholinesterase and inhibits the hydrolysis of acetylcholine, thus increasing the availability of acetylcholine at the synapses, enhancing cholinergic transmission.
What is a medication used for all stages of dementia?
Cholinesterase inhibitors (Aricept®, Exelon®, Razadyne®) The cholinesterase inhibitors most commonly prescribed are: Donepezil (Aricept®): approved to treat all stages of Alzheimer’s disease.
Does donepezil affect blood pressure?
Donepezil affects parasympathetic innervation of the myocardium. The main effect is suppression of atrioventricular node conduction. Beta-adrenergic blocking agents, such as metoprolol, block catecholamine-induced increases in heart rate, myocardial contractility and blood pressure2.
Who needs donepezil?
Donepezil comes in two oral tablet forms: tablet and disintegrating tablet (ODT). Donepezil oral tablet is used to treat dementia due to mild, moderate, and severe Alzheimer’s disease. This drug isn’t a cure for Alzheimer’s disease, but it may help slow down how quickly symptoms progress.
What is the initial diagnosis for donepezil?
Donepezil will only be initiated in primary care within its licenced indication i.e. for the symptomatic treatment of mild to moderately severe Alzheimer’s dementia.
What is donepezil 10 mg prescribed for?
Donepezil is used in the treatment of alzheimer’s disease and belongs to the drug class cholinesterase inhibitors. Risk cannot be ruled out during pregnancy. Donepezil 10 mg is not a controlled substance under the Controlled Substances Act (CSA).
When should donepezil be taken?
Donepezil should be taken once a day at bedtime, with or without food. If you are taking the regular tablet form of donepezil, it is recommended that you take it with a drink of water or other fluid. Do not crush, chew, split, or dissolve the regular tablets.
Why is donepezil prescribed?
Donepezil is used for the treatment of symptoms caused by Alzheimer’s dementia. While the medicine does not cure or slow the progression of the disease, it can be used to help improve memory, attention, reason, language, and the ability to perform simple daily tasks.
Does donepezil HCl interact with other medications?
Donepezil may cause side effects when taken with certain anesthesia drugs. Tell your doctor or dentist that you’re taking this drug before you have any medical or dental surgeries or procedures. Donepezil oral tablet can interact with other medications, vitamins, or herbs you may be taking.