What is CDH2 gene?
CDH2 (Cadherin 2) is a Protein Coding gene. Diseases associated with CDH2 include Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome and Arrhythmogenic Right Ventricular Dysplasia, Familial, 14. Among its related pathways are ERK Signaling and CDO in myogenesis.
What does a cadherin do?
Cadherins are transmembrane proteins that mediate cell–cell adhesion in animals. By regulating contact formation and stability, cadherins play a crucial role in tissue morphogenesis and homeostasis.
What is N-cadherin a marker for?
N-cadherin serves as an indicator of ongoing EMT and its expression has been correlated with the development of various types of carcinoma [49,50,51,52].
What condition would result if there is a mutation in the gene CDH2?
After 20 years of research scientists at the University of Cape Town have identified the mutations in a gene called CDH2, or cadherin 2, that’s responsible for an inherited form of heart muscle disease that affects the right side of the heart in a condition known as cardiomyopathy.
What is cadherin switch?
Cadherin isoform switching (cadherin switching) occurs during normal developmental processes to allow cell types to segregate from one another. Tumor cells often recapitulate this activity and the result is an aggressive tumor cell that gains the ability to leave the site of the tumor and metastasize.
Is sudden death genetic?
The evidence that genes have a role to play in sudden death due to coronary artery disease has gathered from family studies. Studies on different ethnic populations have documented an increased predisposition to sudden death as a specific mode of death in certain families.
What gene causes sudden cardiac death?
The gene, called CDH2, causes arrhythmogenic right ventricle cardiomyopathy (ARVC), which is a genetic disorder that predisposes patients to cardiac arrest and is a major cause of unexpected death in seemingly healthy young people.
What is the function of the N-cadherin gene?
N-cadherin, also known as Cadherin-2 (CDH2) or neural cadherin (NCAD) is a protein that in humans is encoded by the CDH2 gene. CDH2 has also been designated as CD325 (cluster of differentiation 325). N-cadherin is a transmembrane protein expressed in multiple tissues and functions to mediate cell–cell adhesion.
Which is better E cadherin or CdH2?
E-cadherin and N-cadherin staining scores could be merged into a cadherin (CDH) logistic index, which showed better discrimination than E-cadherin or N-cadherin alone. High CDH2 expression is associated with angiogenesis in lung adenocarcinoma.
Which is part of the NCAD gene is CDH2?
N-cadherin, also known as Cadherin-2 ( CDH2) or neural cadherin ( NCAD) is a protein that in humans is encoded by the CDH2 gene. CDH2 has also been designated as CD325 ( cluster of differentiation 325).
What is the role of cadherin 2 in zebrafish?
Cadherin-2 plays a key role during zebrafish granule cell migration by continuously coordinating cell-cell contacts and cell polarity through the remodeling of adherens junctions. data reveal a novel role for cdh2 in the establishment of circuits by peripheral sensory neurons